| dbo:alternativeName
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- Evekeo,Adderall,ref|Adderall and other mixed amphetamine salts products such as Mydayis are not racemic amphetamine – they are a mixture composed of equal parts racemate and dextroamphetamine.
See Mixed amphetamine salts for more information about the mixture, and [[#Pharmaceutical products|this section]] for information about the various mixtures of amphetamine enantiomers marketed.|name=AdderallDiff|group=note[[#Pharmaceutical products (en)
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| dbo:chEBI
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| dbo:chEMBL
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| dbo:class
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| dbo:description
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- cheemesch Verbindung (lb)
- chemická sloučenina (cs)
- chemická zlúčenina (sk)
- chemiese verbinding (af)
- component quimic (oc)
- compost químic (ca)
- composto químico (gl)
- compuesto quimico (an)
- compuesto químico (es)
- compuestu químicu (ast)
- compus chimic (ro)
- kemia kombinaĵo (eo)
- kemisk forbindelse (da)
- kjemisk sambinding (nn)
- komponim kimik (sq)
- konposatu kimiko (eu)
- pair of enantiomers (en)
- para enancjomerów (pl)
- ķīmisks savienojums (lv)
- քիմիական միացություն (hy)
- রাসায়নিক যৌগ (bn)
- 약물의 종류 (ko)
- مركب كيميائي منشط للجهاز العصبي (ar)
- стимулятор центральной нервной системы (ru)
- Compostos químicos (pt)
- Druga (ga)
- Merkezi sinir sistemi uyarıcısı (tr)
- chemische Verbindung und Droge (de)
- chemische verslavende stof en harddrug (nl)
- chất kích thích hệ thần kinh trung ương (vi)
- lääke- ja huumausaine (fi)
- mesterségesen előállított szerves vegyület (hu)
- mélange d'isomères (fr)
- senyawa kimia, pasangan enansiomer (in)
- syntetiskt centralstimulerande medel (sv)
- farmaco con proprietà anoressizzanti e psicostimolanti (it)
- 中枢神経興奮作用を有する有機化合物 (ja)
- חומר ממריץ (iw)
- نوعی ماده محرک (fa)
- 中枢神经系统兴奋剂 (zh)
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| dbo:drugbank
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| dbo:fdaUniiCode
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| dbo:inn
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| dbo:kegg
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| dbo:medlinePlus
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| dbo:pubchem
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| dbo:thumbnail
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| dbo:wikiPageExternalLink
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| dbo:wikiPageWikiLink
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| dbp:addictionLiability
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| dbp:align
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| dbp:alt
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- Diagram of amphetamine synthesis by Knoevenagel condensation (en)
- Diagram of a chiral resolution of racemic amphetamine and a stereoselective synthesis (en)
- Graphical representation of Amphetamine stereoisomers (en)
- An image of phenyl-2-nitropropene and amphetamine hydrochloride (en)
- An image of amphetamine free base (en)
- An image of the amphetamine compound (en)
- Diagram of amphetamine via Ritter synthesis (en)
- Diagram of amphetamine synthesis by Friedel–Crafts alkylation (en)
- Diagram of amphetamine synthesis by the Leuckart reaction (en)
- Diagram of amphetamine synthesis from phenylacetone and ammonia (en)
- Diagram of amphetamine synthesis via Hofmann and Curtius rearrangements (en)
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| dbp:atcPrefix
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| dbp:atcSuffix
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| dbp:bioavailability
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- (en)
- ~90% (en)
- Oral: (en)
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| dbp:boilingNotes
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| dbp:boilingPoint
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| dbp:c
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| dbp:caption
|
- dbr:Phenyl-2-nitropropene
- (en)
- and (en)
- Method 4: Synthesis via Hofmann and Curtius rearrangements (en)
- A vial of the colorless amphetamine free base (en)
- Amphetamine hydrochloride (en)
- Bottom: Stereoselective synthesis of amphetamine (en)
- Method 1: Synthesis by the Leuckart reaction (en)
- Method 2: Synthesis by Friedel–Crafts alkylation (en)
- Method 3: Ritter synthesis (en)
- Method 5: Synthesis by Knoevenagel condensation (en)
- The skeletal structures of (en)
- Top: Chiral resolution of amphetamine (en)
- Method 6: Synthesis using phenylacetone and ammonia (en)
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| dbp:casNumber
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| dbp:chebi
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| dbp:chembl
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| dbp:chemspiderid
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| dbp:chirality
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| dbp:class
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| dbp:collapse
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| dbp:dailymedid
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| dbp:density
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| dbp:densityNotes
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| dbp:dependencyLiability
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- Psychological: Moderate (en)
- Physical: None (en)
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| dbp:direction
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| dbp:displayAuthors
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| dbp:drugbank
| |
| dbp:durationOfAction
|
- 3 (xsd:integer)
- 8 (xsd:integer)
- hours (en)
- dosing: (en)
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| dbp:eliminationHalfLife
|
- 7 (xsd:integer)
- 9 (xsd:integer)
- 11 (xsd:integer)
- : (en)
- hours (en)
- pH-dependent: (en)
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| dbp:excretion
|
- (en)
- Primarily renal; (en)
- pH-dependent (en)
- range: 1–75% (en)
|
| dbp:h
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| dbp:header
|
- Racemic amphetamine (en)
- Signaling cascade in the nucleus accumbens that results in amphetamine addiction (en)
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| dbp:headerAlign
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| dbp:height
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| dbp:image
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- Amphetamine Freebase.png (en)
- Amphetamine Friedel-Crafts alkylation.svg (en)
- Amphetamine Hofmann Curtius Synthesis.svg (en)
- Amphetamine Knoevenagel synthesis.svg (en)
- Amphetamine Leukart synthesis.svg (en)
- Amphetamine Ritter Synthesis.svg (en)
- Amphetamine and P2P.png (en)
- Amphetamine p2p ammonia synthesis.svg (en)
- Amphetamine resolution and chiral synthesis.svg (en)
- Amfetamine enantiomers ball-and-stick models labelled.png (en)
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| dbp:imageBgColor
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| dbp:imageClass
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| dbp:imageLeft
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| dbp:imageTop
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| dbp:imageWidth
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| dbp:inn
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| dbp:iupacName
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| dbp:iupharLigand
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| dbp:kegg
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| dbp:legalAu
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| dbp:legalBr
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| dbp:legalCa
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| dbp:legalDe
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| dbp:legalNz
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| dbp:legalUk
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| dbp:legalUn
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- Psychotropic Schedule II (en)
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| dbp:legalUs
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| dbp:lisdexamfetamine
|
- Compared to other amphetamine pharmaceuticals, lisdexamfetamine may have a lower liability for abuse as a recreational drug. (en)
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| dbp:medlineplus
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| dbp:meltingPoint
| |
| dbp:metabolism
| |
| dbp:metabolites
|
- 4 (xsd:integer)
- , (en)
- , benzoic acid, hippuric acid, norephedrine, phenylacetone (en)
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| dbp:n
| |
| dbp:nameListStyle
| |
| dbp:niaidChemdb
| |
| dbp:onset
|
- 1.500000 (xsd:double)
- 30 (xsd:integer)
- hours (en)
- minutes (en)
- dosing: (en)
|
| dbp:other
|
- Lisdexamfetamine is a prodrug of dextroamphetamine. It is not as sensitive to pH as amphetamine when being absorbed in the gastrointestinal tract. Following absorption into the blood stream, lisdexamfetamine is completely converted by red blood cells to dextroamphetamine and the amino acid (L)-lysine by hydrolysis via undetermined aminopeptidase enzymes. This is the rate-limiting step in the bioactivation of lisdexamfetamine. The elimination half-life of lisdexamfetamine is generally less than 1 hour. Due to the necessary conversion of lisdexamfetamine into dextroamphetamine, levels of dextroamphetamine with lisdexamfetamine peak about one hour later than with an equivalent dose of immediate-release dextroamphetamine. Presumably due to its rate-limited activation by red blood cells, intravenous administration of lisdexamfetamine shows greatly delayed time to peak and reduced peak levels compared to intravenous administration of an equivalent dose of dextroamphetamine. The pharmacokinetics of lisdexamfetamine are similar regardless of whether it is administered orally, intranasally, or intravenously. Hence, in contrast to dextroamphetamine, parenteral use does not enhance the subjective effects of lisdexamfetamine. Because of its behavior as a prodrug and its pharmacokinetic differences, lisdexamfetamine has a longer duration of therapeutic effect than immediate-release dextroamphetamine and shows reduced misuse potential. (en)
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| dbp:proteinBound
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| dbp:pubchem
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| dbp:receptors
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| dbp:routesOfAdministration
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- Medical: Oral, intravenous (en)
- Recreational: Oral, insufflation, rectal, intravenous, intramuscular (en)
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| dbp:smiles
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| dbp:stdinchi
| |
| dbp:stdinchikey
|
- KWTSXDURSIMDCE-UHFFFAOYSA-N (en)
|
| dbp:synonyms
|
- α-methylphenethylamine (en)
|
| dbp:tradename
|
- Evekeo, Adderall,ref|Adderall and other mixed amphetamine salts products such as Mydayis are not racemic amphetamine – they are a mixture composed of equal parts racemate and dextroamphetamine.
See Mixed amphetamine salts for more information about the mixture, and [[#Pharmaceutical products|this section]] for information about the various mixtures of amphetamine enantiomers marketed.|name=AdderallDiff|group=note [[#Pharmaceutical products (en)
|
| dbp:unii
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| dbp:verifiedfields
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| dbp:verifiedrevid
| |
| dbp:watchedfields
| |
| dbp:width
|
- 300 (xsd:integer)
- 372 (xsd:integer)
- 610 (xsd:integer)
|
| dbp:wikiPageUsesTemplate
| |
| dct:subject
| |
| gold:hypernym
| |
| rdf:type
| |
| rdfs:label
|
- Amphetamine (en)
- Amphetamin (de)
- أمفيتامين (ar)
- Amfetamina (ca)
- Amfetamin (cs)
- Αμφεταμίνη (el)
- Amfetamino (eo)
- Anfetamina (eu)
- Anfetamina (es)
- Amfataimín (ga)
- Amfetamin (in)
- Amphétamine (fr)
- Amfetamina (it)
- アンフェタミン (ja)
- 암페타민 (ko)
- Amfetamina (pl)
- Anfetamina (pt)
- Amfetamine (nl)
- Амфетамін (uk)
- Амфетамин (ru)
- Amfetamin (sv)
- 苯丙胺 (zh)
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