| dbo:abstract
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- Intracellular delivery is the process of introducing external materials into living cells. Materials that are delivered into cells include nucleic acids (DNA and RNA), proteins, peptides, impermeable small molecules, synthetic nanomaterials, organelles, and micron-scale tracers, devices and objects.Such molecules and materials can be used to investigate cellular behavior, engineer cell operations or correct a pathological function. Medical applications of intracellular delivery range from in vitro fertilisation (IVF) and mRNA vaccinesto gene therapyand preparation of CAR-T cells.Industrial applications include protein production, biomanufacture, and genetic engineering of plants and animals.Intracellular delivery is a fundamental technique in the study of biology and genetics, such as the use of DNA plasmid transfection to investigate protein function in living cells.A wide range of approaches exist for performing intracellular delivery including biological, chemical and physical techniques that work through either membrane disruption or packaging the delivery material in carriers. Intracellular delivery is at the intersection of cell biology and technology, and is related to many fields across science and medicine including genetics, biotechnology, bioengineering and drug delivery. (en)
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| rdfs:comment
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- Intracellular delivery is the process of introducing external materials into living cells. Materials that are delivered into cells include nucleic acids (DNA and RNA), proteins, peptides, impermeable small molecules, synthetic nanomaterials, organelles, and micron-scale tracers, devices and objects.Such molecules and materials can be used to investigate cellular behavior, engineer cell operations or correct a pathological function. (en)
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