About: Mipomersen

Property	Value
dbo:abstract	Mipomersen (INN; trade name Kynamro) is a drug used to treat homozygous familial hypercholesterolemia and is administered by subcutaneous injection. There is a serious risk of liver damage from this drug and it can only be prescribed in the context of a risk management plan. (en) Le mipomersen est une molécule développée comme médicament et qui est en cours de test dans le traitement des hypercholestérolémies. (fr)
dbo:alternativeName	Kynamro (en)
dbo:casNumber	1000120-98-8 629167-92-6
dbo:chEMBL	502097
dbo:drugbank	DB05528
dbo:fdaUniiCode	18EAY4870E 9GJ8S4GU0M
dbo:kegg	D08946
dbo:pubchem	44564107
dbo:thumbnail	wiki-commons:Special:FilePath/Mipomersen_sodium_colored.svg?width=300
dbo:wikiPageID	18978054 (xsd:integer)
dbo:wikiPageLength	14422 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID	1069252261 (xsd:integer)
dbo:wikiPageWikiLink	dbr:Endonuclease dbr:Messenger_RNA dbr:Deoxyribonucleic_acid dbr:Deoxyribose dbc:Therapeutic_gene_modulation dbr:Nuclease dbr:Low-density_lipoprotein dbr:Transaminase dbr:Thiophosphate dbr:Angina dbr:Liver dbr:Subcutaneous_injection dbr:Edema dbr:European_Medicines_Agency dbr:Familial_hypercholesterolemia dbr:Ribonucleic_acid dbr:Risk_Evaluation_and_Mitigation_Strategies dbc:Hypolipidemic_agents dbr:International_Nonproprietary_Name dbr:Ionis_Pharmaceuticals dbc:Antisense_RNA dbc:Sanofi dbr:Translation_(biology) dbr:Pharmacokinetic dbr:Apolipoprotein_B-100 dbr:Black_box_warning dbr:Exonuclease dbr:Ribonuclease_H dbr:Very_low-density_lipoprotein dbr:Phosphodiester dbr:Antisense_oligonucleotide dbr:Nucleases dbr:Genzyme_Corporation dbr:Hepatic_steatosis dbr:Liver_damage dbr:File:Mipomersen.svg dbr:File:Mipomersen_sodium.svg
dbp:atcPrefix	10.0
dbp:atcSuffix	AX11 (en)
dbp:c	230 (xsd:integer)
dbp:casNumber	629167 (xsd:integer) 1000120 (xsd:integer)
dbp:chembl	502097 (xsd:integer)
dbp:chemspiderid	24710309 (xsd:integer)
dbp:drugbank	DB05528 (en)
dbp:eliminationHalfLife	-5259600.0
dbp:excretion	86400.0
dbp:h	305 (xsd:integer)
dbp:index2Label	sodium salt (en)
dbp:iupacName	2 (xsd:integer)
dbp:jmol	None (en)
dbp:kegg	D08946 (en)
dbp:legalUs	Rx-only (en)
dbp:metabolism	Nucleases (en)
dbp:n	67 (xsd:integer)
dbp:na	19 (xsd:integer)
dbp:o	122 (xsd:integer)
dbp:p	19 (xsd:integer)
dbp:pregnancyUs	B (en)
dbp:proteinBound	≥90% (en)
dbp:pubchem	44564107 (xsd:integer)
dbp:routesOfAdministration	dbr:Subcutaneous_injection
dbp:s	19 (xsd:integer)
dbp:smiles	COCCO[C@@H]1[C@H][C@H]COPO (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	XLTMQWVJFPYGMC-QVKFEXRMSA-N (en)
dbp:synonyms	ISIS 301012 (en)
dbp:tradename	Kynamro (en)
dbp:unii	9 (xsd:integer) 18 (xsd:integer)
dbp:width	300 (xsd:integer)
dbp:wikiPageUsesTemplate	dbt:Citation_needed dbt:Drugbox dbt:Reflist dbt:Rp dbt:Short_description dbt:Cascite dbt:Fdacite dbt:Drugs.com dbt:Lipid_modifying_agents
dcterms:subject	dbc:Therapeutic_gene_modulation dbc:Hypolipidemic_agents dbc:Antisense_RNA dbc:Sanofi
gold:hypernym	dbr:Drug
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:Agent109190918 yago:CausalAgent100007347 yago:PhysicalEntity100001930 yago:WikicatHypolipidemicAgents dbo:Drug
rdfs:comment	Mipomersen (INN; trade name Kynamro) is a drug used to treat homozygous familial hypercholesterolemia and is administered by subcutaneous injection. There is a serious risk of liver damage from this drug and it can only be prescribed in the context of a risk management plan. (en) Le mipomersen est une molécule développée comme médicament et qui est en cours de test dans le traitement des hypercholestérolémies. (fr)
rdfs:label	Mipomersen (fr) Mipomersen (en)
owl:sameAs	freebase:Mipomersen yago-res:Mipomersen wikidata:Mipomersen dbpedia-fr:Mipomersen dbpedia-sh:Mipomersen dbpedia-sr:Mipomersen dbpedia-vi:Mipomersen https://global.dbpedia.org/id/33pj4
prov:wasDerivedFrom	wikipedia-en:Mipomersen?oldid=1069252261&ns=0
foaf:depiction	wiki-commons:Special:FilePath/Mipomersen.svg wiki-commons:Special:FilePath/Mipomersen_sodium.svg wiki-commons:Special:FilePath/Mipomersen_sodium_colored.svg
foaf:isPrimaryTopicOf	wikipedia-en:Mipomersen
is dbo:product of	dbr:Ionis_Pharmaceuticals
is dbo:wikiPageRedirects of	dbr:Kynamro dbr:ATC_code_C10AX11 dbr:ATCvet_code_QC10AX11 dbr:Mipomersen_sodium dbr:ISIS_301012
is dbo:wikiPageWikiLink of	dbr:Sanofi dbr:Antisense_RNA dbr:Antisense_therapy dbr:Intracellular_delivery dbr:Kynamro dbr:Thiophosphate dbr:Organothiophosphate dbr:Gapmer dbr:Lipid-lowering_agent dbr:Familial_hypercholesterolemia dbr:ATC_code_C10AX11 dbr:ATCvet_code_QC10AX11 dbr:Ionis_Pharmaceuticals dbr:ATC_code_C10 dbr:Sense_(molecular_biology) dbr:Mipomersen_sodium dbr:ISIS_301012
is dbp:products of	dbr:Ionis_Pharmaceuticals
is foaf:primaryTopic of	wikipedia-en:Mipomersen