| dbp:quote
|
- Process of partial or total alteration of the native secondary, and/or tertiary, and/or quaternary structures of proteins or nucleic acids resulting in a loss of bioactivity.
Note 1: Modified from the definition given in ref.
Note 2: Denaturation can occur when proteins and nucleic acids are subjected to elevated temperature or to extremes of pH, or to nonphysiological concentrations of salt, organic solvents, urea, or other chemical agents.
Note 3: An enzyme loses its ability to alter or speed up a chemical reaction when it is denaturized. (en)
|
