About: Progesterone (medication)

Property	Value
dbo:alternativeName	Prometrium, Utrogestan, Endometrin, others (en)
dbo:casNumber	57-83-0
dbo:chEBI	17026
dbo:chEMBL	103
dbo:class	dbr:Progestogen_(medication) dbr:Neurosteroid dbr:Mineralocorticoid_receptor_antagonist
dbo:description	medication and naturally occurring steroid hormone (en)
dbo:drugbank	DB00396
dbo:fdaUniiCode	4G7DS2Q64Y
dbo:kegg	D00066
dbo:medlinePlus	a604017
dbo:pubchem	5994
dbo:thumbnail	wiki-commons:Special:FilePath/Progesterone.svg?width=300
dbo:wikiPageWikiLink	dbr:Implantation_(human_embryo) dbr:Cardiac_dysfunction dbr:Cardiovascular_health dbr:Duration_of_action dbr:First-pass_effect dbr:Chemical_synthesis dbr:Colloid dbr:Migraine dbr:Breastfeeding dbr:Preterm_birth dbr:Bone dbr:Double_bond dbr:Agonist dbr:Levonorgestrel dbr:Mifepristone dbr:Paroxetine dbr:Pregnenolone dbr:Receptor_antagonist dbr:Sertraline dbr:Diosgenin dbr:Sexual_desire dbr:Alfadolone dbr:Breast_development dbr:Microsphere dbr:Active_metabolite dbr:Medrogestone dbr:Central_nervous_system_depression dbr:Argentina dbr:Belgium dbr:Belize dbr:Brain dbr:Bulgaria dbr:Chile dbr:Colombia dbr:Cyprus dbr:Czech_Republic dbr:Ecuador dbr:El_Salvador dbr:English_language dbr:Ethiopia dbr:France dbr:French_language dbr:Georgia_(country) dbr:German_language dbr:Germany dbr:Guatemala dbr:Headache dbr:Honduras dbr:Hungary dbr:India dbr:Italy dbr:Japan dbr:Latin dbr:Lebanon dbr:Malaysia dbr:Malta dbr:Mexico dbr:Monaco dbr:Nicaragua dbr:Oman dbr:Paraguay dbr:Peru dbr:Poland dbr:Portugal dbr:Romania dbr:Russia dbr:Serbia dbr:Singapore dbr:Skin dbr:Slovakia dbr:South_Africa dbr:Spain dbr:Spanish_language dbr:Switzerland dbr:Taiwan dbr:Thailand dbr:Tokyo dbr:Tunisia dbr:Turkey dbr:Ukraine dbr:United_Kingdom dbr:United_States dbr:Venezuela dbr:Vietnam dbr:Water dbr:Norethisterone dbr:Progestogen_(medication) dbr:Selective_serotonin_reuptake_inhibitor dbr:Vaginal_ring dbr:Hydroxydione dbr:Hydroxyprogesterone_caproate dbr:Diketone dbr:Contraindication dbr:Abortion dbr:Anemia dbr:Breast dbr:Canada dbr:Egypt dbr:Epidemiology dbr:Fatigue dbr:Hong_Kong dbr:Liver dbr:Madison,_Wisconsin dbr:Muscle dbr:Portuguese_language dbr:Semen dbr:Sleep dbr:Uterus dbr:Vagina dbr:Capsule_(pharmacy) dbr:Confusion dbr:Fat dbr:Mammography dbr:Catamenial_epilepsy dbr:Reproductive_system_disease dbc:Anticonvulsants dbc:Sigma_antagonists dbr:Human_serum_albumin dbr:Benzodiazepine dbr:Chemical_structure dbr:Diabetes dbr:Edema dbr:Japanese_people dbr:Pituitary_gland dbr:Toxicity dbr:Traumatic_brain_injury dbr:Alcohol_(drug) dbr:Anxiolytic dbr:Asthma dbr:Breast_pain dbr:Cardiovascular_disease dbr:Constipation dbr:Depression_(mood) dbr:Dizziness dbr:Hormone dbr:Medication dbr:Menstruation dbr:Pregnancy dbr:Vaginal_discharge dbr:Analgesic dbr:Assisted_reproductive_technology dbr:Ectopic_pregnancy dbr:Miscarriage dbr:Oil dbr:Progesterone dbr:Scientific_journal dbr:Topical_medication dbr:Vaginal_bleeding dbr:Back_pain dbr:Benzyl_alcohol dbr:Nanoparticle dbr:Birth_control dbr:Infertility dbr:Natural_product dbr:Functional_group dbr:Hypotension dbr:Hypothalamus dbr:Ketone dbr:Trademark dbr:Endometrial_hyperplasia dbr:Pap_test dbr:Upjohn dbr:Hyperthermia dbr:Injection_(medicine) dbr:Mood_(psychology) dbr:Dydrogesterone dbr:Minaxolone dbr:Case_report dbr:Parenteral dbr:Injection_site_reaction dbr:Irritability dbr:Nausea dbr:Growth_hormone dbr:Pharmacodynamics dbr:Placebo dbr:Azoospermia dbr:Meta-analysis dbr:Aqueous_solution dbr:Estrogen_(medication) dbr:Pregnanediol dbr:Allopregnanolone dbr:Neurosteroid dbr:Pregnane dbr:Feminizing_hormone_therapy dbr:Pregnanetriol dbr:Promegestone dbr:Quality_of_life dbr:Renanolone dbr:Robert_Benjamin_Greenblatt dbr:Estradiol_hemisuccinate/progesterone dbr:Central_nervous_system dbr:Crystal dbr:Epilepsy dbr:Local_anesthetic dbr:Paracetamol dbr:Spermatogenesis dbr:Urine dbr:Antiandrogen dbr:Breast_cancer dbr:Dyspareunia dbr:Schering_AG dbr:Sedation dbr:5α-Reductase dbr:17α-Hydroxyprogesterone dbr:Aldosterone dbr:Coagulation dbr:Dysphoria dbr:Gel dbr:Glucocorticoid dbr:Hormone_replacement_therapy dbr:Hypogonadism dbr:Libido dbr:Menopause dbr:Ovulation dbr:Pessary dbr:Steroid dbr:Suppository dbr:Lidocaine dbr:Premenstrual_syndrome dbr:11-Deoxycorticosterone dbr:Endometrial_cancer dbr:American_Academy_of_Pediatrics dbr:Bioavailability dbr:Brand_name dbr:Pregnane_X_receptor dbr:Estradiol_benzoate dbr:Ejaculation dbr:Progesterone_receptor dbr:Estradiol/progesterone dbr:P1-185 dbr:Progesterone_receptor_A dbr:Progesterone_vaginal_ring dbr:Estrogenic_substances dbr:Lipid_profile dbr:Cervix dbr:Hormonal_contraception dbr:Neurotransmitter dbr:Sex_hormone dbr:Testosterone dbr:Gonad dbr:Sedative dbr:Tablet_(pharmacy) dbr:Observational_study dbr:Intrauterine_device dbr:Thromboembolism dbr:5α-Reductase_inhibitor dbr:Anesthetic dbr:CYP3A4 dbr:Diethylstilbestrol dbr:Dutasteride dbr:Finasteride dbr:Fluoxetine dbr:Intramuscular_injection dbr:Micelle dbr:Mineralocorticoid dbr:Nuclear_receptor dbr:Rectal_administration dbr:Steroid_hormone dbr:Potency_(pharmacology) dbr:Extract dbr:Cream_(pharmacy) dbr:Medroxyprogesterone_acetate dbr:Pregnanolone dbr:Estradiol_hemisuccinate dbr:Quingestrone dbr:Corpus_luteum dbr:Symptom dbr:Inhibitory_postsynaptic_potential dbr:Adverse_effect dbr:Medical_prescription dbr:Noretynodrel dbr:Androgen dbr:Bile dbr:GABAA_receptor dbr:Hypnotic dbr:Lightheadedness dbr:Adipose_tissue dbr:Antiestrogen dbr:Cell_proliferation dbr:Emulsion dbr:Liver_disease dbr:Mineralocorticoid_receptor dbr:-ene dbr:Prodrug dbr:Estradiol_(medication) dbr:Norethisterone_acetate dbc:5α-Reductase_inhibitors dbc:Antigonadotropins dbc:Antimineralocorticoids dbr:Anticonvulsant dbr:Antihypertensive dbr:Cognitive_impairment dbr:Oral_administration dbr:Side_effect dbr:Sexual_function dbr:Sublingual_administration dbr:Micronization dbr:Dihydroprogesterone dbr:Route_of_administration dbr:Cognition
dbp:atcPrefix	G03 (en)
dbp:atcSuffix	DA04 (en)
dbp:bioavailability	Oral: <2.4% (en) Vaginal : 4–8% (en)
dbp:c	21 (xsd:integer)
dbp:casNumber	57 (xsd:integer)
dbp:chebi	17026 (xsd:integer)
dbp:chembl	103 (xsd:integer)
dbp:chemspiderid	5773 (xsd:integer)
dbp:class	dbr:Progestogen_(medication) dbr:Neurosteroid dbr:Mineralocorticoid_receptor_antagonist
dbp:displayAuthors	6 (xsd:integer)
dbp:drugName	Progesterone (en)
dbp:drugbank	DB00396 (en)
dbp:eliminationHalfLife	-5400.0 (dbd:second) 18000.0 (dbd:second) -25200.0 (dbd:second) -180000.0 (dbd:second) -100800.0 (dbd:second) -144000.0 (dbd:second) -64800.0 (dbd:second)
dbp:excretion	Bile and urine (en)
dbp:h	30 (xsd:integer)
dbp:image	Progesterone-3D-balls.png (en)
dbp:iupacName	-17 (xsd:integer)
dbp:iupharLigand	2377 (xsd:integer)
dbp:kegg	D00066 (en)
dbp:legalAu	S4 (en)
dbp:legalCa	Rx-only (en)
dbp:legalStatus	Rx-only (en)
dbp:medlineplus	a604017 (en)
dbp:meltingPoint	126 (xsd:integer)
dbp:metabolism	• (en) Mainly liver: (en) • and (en) • 17α-Hydroxylase (en) • 21-Hydroxylase (en) • 5α- and 5β-reductase (en) • Conjugation (en)
dbp:metabolites	(en) • 11-Deoxycorticosterone (en) • 17α-Hydroxyprogesterone (en) • 20α-Hydroxyprogesterone (en) • Dihydroprogesterones (en) • Pregnanediols (en) • Pregnanetriols (en) • Pregnanolones (en)
dbp:nameListStyle	vanc (en)
dbp:o	2 (xsd:integer)
dbp:proteinBound	98 (xsd:integer) • : 18% (en) • : <1% (en) • Albumin: 80% (en) • Free: 1–2% (en)
dbp:pubchem	5994 (xsd:integer)
dbp:routesOfAdministration	dbr:Topical_medication dbr:Intrauterine_device dbr:Intramuscular_injection dbr:Rectal_administration dbr:Subcutaneous_administration dbr:Oral_administration dbr:Sublingual_administration dbr:Intravaginal_administration
dbp:smiles	CC[C@H]1CC[C@@H]2[C@@]1C (en)
dbp:specificRotation	[α]D25 = +172 to +182° (en)
dbp:stdinchi	InChI=1S/C21H30O2/c1-1317-6-7-18-16-5-4-14-12-158-10-20199-11-213/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 (en)
dbp:stdinchikey	RJKFOVLPORLFTN-LEKSSAKUSA-N (en)
dbp:synonyms	P4; Pregnenedione; Pregn-4-ene-3,20-dione (en)
dbp:title	dbr:Pharmacodynamics
dbp:titlestyle	background:#ccccff (en)
dbp:tradename	Prometrium, Utrogestan, Endometrin, others (en)
dbp:unii	4 (xsd:integer)
dbp:verifiedfields	verified (en)
dbp:verifiedrevid	444066687 (xsd:integer)
dbp:watchedfields	verified (en)
dbp:width	225 (xsd:integer)
dbp:wikiPageUsesTemplate	dbt:Risk_of_breast_cancer_with_menopausal_...ration_in_large_observational_studies dbt:Risk_of_breast_cancer_with_menopausal_...herapy_in_large_observational_studies dbt:Available_forms_of_progesterone dbt:Worldwide_epidemiological_evidence_on_..._risk_with_menopausal_hormone_therapy dbt:Glucocorticoid_receptor_modulators dbt:Mineralocorticoid_receptor_modulators dbt:Mineralocorticoids_and_antimineralocorticoids dbt:Progesterone dbt:Progesterone_receptor_modulators dbt:Progestogens_and_antiprogestogens dbt:Sigma_receptor_modulators dbt:Xenobiotic-sensing_receptor_modulators dbt:Abbr dbt:Abbrlink dbt:About dbt:As_of dbt:Authority_control dbt:Cascite dbt:Chemspidercite dbt:Cite_journal dbt:Cs1_config dbt:Distinguish dbt:Drugbankcite dbt:Drugs.com dbt:Ebicite dbt:Fdacite dbt:GABAA_receptor_positive_modulators dbt:Infobox_drug dbt:Keggcite dbt:Main dbt:Navboxes dbt:Nbsp dbt:Nicotinic_acetylcholine_receptor_modulators dbt:Portal_bar dbt:Redirect dbt:Refbegin dbt:Refend dbt:Reflist dbt:See_also dbt:Short_description dbt:Stdinchicite dbt:TOC_limit dbt:Use_dmy_dates
dct:subject	dbc:Orphan_drugs dbc:Anticonvulsants dbc:Sigma_antagonists dbc:5α-Reductase_inhibitors dbc:Antigonadotropins dbc:Antimineralocorticoids dbc:Neurosteroids dbc:Obstetric_drugs dbc:Diketones dbc:Glucocorticoids dbc:Progestogens dbc:Glycine_receptor_antagonists dbc:Galactagogues dbc:Antihypertensive_agents dbc:General_anesthetics dbc:Hypnotics dbc:Progesterone dbc:Hepatotoxins dbc:Prolactin_releasers dbc:GABAA_receptor_positive_allosteric_modulators dbc:Neuroprotective_agents dbc:Nicotinic_antagonists dbc:Sedatives dbc:Drugs_developed_by_Merck dbc:Pregnanes dbc:Alkene_derivatives dbc:Pregnane_X_receptor_agonists dbc:Drugs_developed_by_AbbVie
rdf:type	owl:Thing dul:ChemicalObject wikidata:Q8386 dbo:ChemicalSubstance dbo:ChemicalSubstance dbo:Drug dbo:Drug dbo:Drug
rdfs:label	Progesterone (medication) (en) بروجستيرون (دواء) (ar) 황체호르몬 (ko)
rdfs:seeAlso	dbr:United_States dbr:Progesterone dbr:Feminizing_hormone_therapy dbr:Estradiol dbr:Progestogen_ester dbr:List_of_progestogens_available
owl:sameAs	yago-res:Progesterone (medication) wikidata:Progesterone (medication) dbpedia-ko:Progesterone (medication) dbpedia-ar:Progesterone (medication) dbpedia-global:Progesterone (medication)
prov:wasDerivedFrom	wikipedia-en:Progesterone_(medication)?oldid=1306598428&ns=0
foaf:depiction	wiki-commons:Special:FilePath/Progesterone-3D-balls.png wiki-commons:Special:FilePath/Progesterone.svg wiki-commons:Special:FilePath/Steroidogenesis.svg wiki-commons:Special:FilePath/000527lg_Prometrium_100_MG_Oral_Capsule.jpg
foaf:isPrimaryTopicOf	wikipedia-en:Progesterone_(medication)
foaf:name	Progesterone (en)
is dbo:license of	dbr:Estradiol/progesterone
is dbo:wikiPageRedirects of	dbr:Hormoflaveine dbr:Hormoluton dbr:Luteal_Hormone dbr:Bio-Luton dbr:Bioidentical_progesterone dbr:Micronised_progesterone dbr:Micronized_progesterone dbr:Natural_progesterone dbr:Prochieve dbr:Progeffik dbr:Progekan dbr:Progelan dbr:Progendo dbr:Progest dbr:ProgestaJect dbr:ProgestaSert dbr:Progestaject dbr:Progestan dbr:Progestasert dbr:Progesterol dbr:Progesteron dbr:Progesterona dbr:Progesterone_congener dbr:Progesterone_congeners dbr:Progesterone_support dbr:Progesteronum dbr:Progestol dbr:Progeston dbr:Progestosol dbr:Progestron dbr:Progestronol dbr:Projestaject dbr:Prolets dbr:Prolidon dbr:Prolutex dbr:Prolutin dbr:Proluton dbr:Prolutone dbr:Prometrium dbr:Prontogest dbr:Prosphere dbr:Protormone dbr:Agolutin dbr:Lingusorbs dbr:Lipo-Lutin dbr:ATC_code_G03DA04 dbr:ATCvet_code_QG03DA04 dbr:Colprosterone dbr:Flavolutan dbr:Fologenon dbr:Gynlutin dbr:Gynoluton dbr:Gynolutone dbr:Geslutin dbr:Gesterol dbr:Gesterol_100 dbr:Gesterol_50 dbr:Gestiron dbr:Gestone dbr:Glanducorpin dbr:Nalutron dbr:Piaponon dbr:Corlutin dbr:Corlutina dbr:Corluvite dbr:Corporin dbr:Crinon dbr:Crinone dbr:Crinone_8% dbr:Cyclogest dbr:Cyclogesterin dbr:Lucorteum dbr:Lucorteum_Sol dbr:Luteina dbr:Luteinique dbr:Luteinol dbr:Luteocrin_Normale dbr:Luteodyn dbr:Luteogan dbr:Luteohormone dbr:Luteol dbr:Luteopur dbr:Luteosan dbr:Luteostab dbr:Luteovis dbr:Lutex dbr:Lutidon dbr:Lutigest dbr:Lutinus dbr:Lutociclina dbr:Lutocuclin_M dbr:Lutocyclin_M dbr:Lutocylin dbr:Lutoform dbr:Lutogyl dbr:Lutren dbr:Lutromone dbr:Oripro dbr:Membrettes dbr:ProSphere dbr:Utrogest dbr:Utrogestan dbr:Syngesterone dbr:Syngestrets dbr:Syntolutan dbr:Thiuranide dbr:Percutacrine dbr:Percutacrine_Luteinique
is dbo:wikiPageWikiLink of	dbr:Hormoflaveine dbr:Hormoluton dbr:Preterm_birth dbr:Desogestrel dbr:Gestodene dbr:Levonorgestrel dbr:Medroxyprogesterone dbr:Metribolone dbr:Algestone dbr:Algestone_acetophenide dbr:Estradiol_benzoate/progesterone/testosterone_propionate dbr:Medrogestone dbr:Megestrol_acetate dbr:Melengestrol_acetate dbr:Mibolerone dbr:Normethandrone dbr:Allylestrenol dbr:Norethisterone dbr:Progestogen_(medication) dbr:Hydroxyprogesterone_caproate dbr:Altrenogest dbr:Trestolone dbr:Trimegestone dbr:Haloprogesterone dbr:Hydroxyprogesterone_acetate dbr:Dienogest dbr:Flugestone_acetate dbr:Traumatic_brain_injury dbr:Dydrogesterone dbr:Gestronol dbr:Hypoestrogenism dbr:Endometriosis dbr:Conjugated_estrogens dbr:Estrogen_(medication) dbr:Proligestone dbr:Triamcinolone_acetonide dbr:Feminizing_hormone_therapy dbr:Promegestone dbr:Estradiol_hemisuccinate/progesterone dbr:Estrone/progesterone dbr:Progesterone_oxime dbr:List_of_sex-hormonal_aqueous_suspensions dbr:Progestogen dbr:Antiandrogen dbr:Hormone_replacement_therapy dbr:Hormone_therapy dbr:ATC_code_G03 dbr:Segesterone_acetate dbr:Estradiol_benzoate dbr:Anagestone_acetate dbr:Functional_hypothalamic_amenorrhea dbr:Methylestradiol dbr:SC-5233 dbr:Spirolactone dbr:Pharmacokinetics_of_estradiol dbr:Pharmacokinetics_of_progesterone dbr:Pharmacology_of_cyproterone_acetate dbr:Dimethyltrienolone dbr:Estradiol/progesterone dbr:P1-185 dbr:SC-8109 dbr:Trimethyltrienolone dbr:Pharmacokinetics_of_testosterone dbr:Estetrol_(medication) dbr:Aminolevulinic_acid_dehydratase_deficiency_porphyria dbr:Danazol dbr:Drospirenone dbr:Progestogen_ester dbr:Prolactin_modulator dbr:Sex_hormone-binding_globulin dbr:Lipid_metabolism dbr:Medroxyprogesterone_acetate dbr:Chlormadinone_acetate dbr:Progestin-induced_virilization dbr:Clometerone dbr:Epiestriol dbr:Estradiol_hemisuccinate dbr:Estradiol_pivalate dbr:Pentagestrone_acetate dbr:Quingestrone dbr:Progestogen_challenge_test dbr:Anabolic_steroid dbr:Galactagogue dbr:Katharina_Dalton dbr:OMP dbr:Benorterone dbr:18-Methylsegesterone_acetate dbr:5α-Dihydroethisterone dbr:Progesterone_3-oxime dbr:Progesterone_dioxime dbr:Pharmacodynamics_of_estradiol dbr:Pharmacodynamics_of_progesterone dbr:Pharmacodynamics_of_spironolactone dbr:Pregnenolone_(medication) dbr:Bioidentical_hormone_replacement_therapy dbr:Spironolactone dbr:Estradiol_(medication) dbr:17α-Allyl-19-nortestosterone dbr:17α-Methyl-19-norprogesterone dbr:Demegestone dbr:Ethisterone dbr:Cyproterone dbr:Micronization dbr:16-Methylene-17α-hydroxyprogesterone_acetate dbr:17α-Bromoprogesterone dbr:Lynestrenol_phenylpropionate dbr:Nomegestrol_acetate dbr:Norgestimate dbr:Norgestrienone dbr:Moxestrol dbr:Gestonorone_caproate dbr:Hydroxyprogesterone_heptanoate dbr:Norgestomet dbr:Retroprogesterone dbr:Trengestone dbr:Estradiol_benzoate/progesterone dbr:VOLT-02 dbr:List_of_progestogens dbr:Estradiol_benzoate/progesterone/methandriol_dipropionate dbr:Estradiol_pivalate/progesterone 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dbr:Gesterol_100 dbr:Gesterol_50 dbr:Gestiron dbr:Gestone dbr:Glanducorpin dbr:Nalutron dbr:Piaponon dbr:Corlutin dbr:Corlutina dbr:Corluvite dbr:Corporin dbr:Crinon dbr:Crinone dbr:Crinone_8% dbr:Cyclogest dbr:Cyclogesterin dbr:Lucorteum dbr:Lucorteum_Sol dbr:Luteina dbr:Luteinique dbr:Luteinol dbr:Luteocrin_Normale dbr:Luteodyn dbr:Luteogan dbr:Luteohormone dbr:Luteol dbr:Luteopur dbr:Luteosan dbr:Luteostab dbr:Luteovis dbr:Lutex dbr:Lutidon dbr:Lutigest dbr:Lutinus dbr:Lutociclina dbr:Lutocuclin_M dbr:Lutocyclin_M dbr:Lutocylin dbr:Lutoform dbr:Lutogyl dbr:Lutren dbr:Lutromone dbr:Oripro dbr:Membrettes dbr:ProSphere dbr:Utrogest dbr:Utrogestan dbr:Syngesterone dbr:Syngestrets dbr:Syntolutan dbr:Thiuranide dbr:Percutacrine dbr:Percutacrine_Luteinique
is dbp:caption of	dbr:Estradiol_hemisuccinate/progesterone dbr:Estrone/progesterone dbr:Estradiol_benzoate/progesterone dbr:Estradiol_pivalate/progesterone
is rdfs:seeAlso of	dbr:Progesterone dbr:Feminizing_hormone_therapy dbr:Quingestrone dbr:Bioidentical_hormone_replacement_therapy
is owl:differentFrom of	dbr:Promegestone
is foaf:primaryTopic of	wikipedia-en:Progesterone_(medication)