| dbo:abstract
|
- Nestoron ist synthetisches Gestagen, welches als Arzneistoff zur Empfängnisverhütung (Kontrazeption), als Hormonersatztherapie in der Menopause und zur Behandlung der Endometriose eingesetzt werden kann. Anders als andere Gestagene kann Nestoron in die Haut eindringen und so über in Form von Gel, Creme, Spray oder Implantat (Vaginalring) appliziert werden. Bei oraler Aufnahme wird die Substanz im Magen-Darm-Trakt zersetzt und zeigt so keine Wirkung. Die 19-Methyl-Substitution und die 16-Methylen-Addition in Nestoron verstärken die Bindung zum Progesteron-Rezeptor um den Faktor 100 im Vergleich zu Progesteron. Im Januar 2004 startete in Australien ein Test, bei dem Nestoron in Form eines Sprays getestet werden soll. Dieses Spray wurde entwickelt von der australischen Firma Acrux und der US-amerikanischen Non-Profit-Organisation . (de)
- Segesterone acetate (SGA), sold under the brand names Nestorone, Elcometrine, and Annovera, is a progestin medication which is used in birth control and in the treatment of endometriosis in the United States, Brazil, and other South American countries. It is available both alone and in combination with an estrogen. It is not effective by mouth and must be given by other routes, most typically as a vaginal ring or implant that is placed into fat. Side effects of SGA are similar to those of other progestins. SGA is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. It has some affinity for the glucocorticoid receptor and has no other important hormonal activity. SGA was developed by the Population Council and was introduced for medical use by 2000. It is under development in the United States and Europe as a gel in combination with estradiol or testosterone for use as a method of birth control in women and in men, respectively. On August 10, 2018, a first-of-its-kind one-year contraceptive vaginal ring containing segesterone acetate in combination with ethinyl estradiol was approved in the United States. It is marketed under the brand name Annovera and is reusable for up to one year as a method of birth control in women. Annovera does not require refrigeration which is very useful for low resource areas. (en)
|
| dbo:alternativeName
|
- Nestorone, Elcometrine, Annovera (en)
|
| dbo:casNumber
| |
| dbo:chEBI
| |
| dbo:chEMBL
| |
| dbo:class
| |
| dbo:fdaUniiCode
| |
| dbo:kegg
| |
| dbo:pubchem
| |
| dbo:thumbnail
| |
| dbo:wikiPageID
| |
| dbo:wikiPageLength
|
- 22354 (xsd:nonNegativeInteger)
|
| dbo:wikiPageRevisionID
| |
| dbo:wikiPageWikiLink
| |
| dbp:atcPrefix
| |
| dbp:bioavailability
| |
| dbp:c
| |
| dbp:casNumber
| |
| dbp:chebi
| |
| dbp:chembl
| |
| dbp:chemspiderid
| |
| dbp:class
| |
| dbp:eliminationHalfLife
|
- 16200.0
- -7200.0
- -259200.0
|
| dbp:h
| |
| dbp:image
|
- Segesterone acetate molecule ball.png (en)
|
| dbp:iupacName
|
- [-17-acetyl-13-methyl-16-methylidene-3-oxo-2,6,7,8,9,10,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate (en)
|
| dbp:kegg
| |
| dbp:legalStatus
| |
| dbp:metabolism
|
- Hydroxylation , reduction (en)
|
| dbp:o
| |
| dbp:proteinBound
| |
| dbp:pubchem
| |
| dbp:routesOfAdministration
| |
| dbp:smiles
| |
| dbp:stdinchi
| |
| dbp:stdinchikey
|
- CKFBRGLGTWAVLG-GOMYTPFNSA-N (en)
|
| dbp:synonyms
|
- SGA; SA; Nestorone; Nestoron; Elcometrine; ST-1435; AC-6844; CS-0411; 16-Methylene-17α-acetoxy-19-norprogesterone; 16-Methylene-17α-acetoxy-19-norpregn-4-ene-3,20-dione (en)
|
| dbp:tradename
|
- Nestorone, Elcometrine, Annovera (en)
|
| dbp:unii
| |
| dbp:width
|
- 215 (xsd:integer)
- 245 (xsd:integer)
|
| dbp:wikiPageUsesTemplate
| |
| dcterms:subject
| |
| rdf:type
| |
| rdfs:comment
|
- Nestoron ist synthetisches Gestagen, welches als Arzneistoff zur Empfängnisverhütung (Kontrazeption), als Hormonersatztherapie in der Menopause und zur Behandlung der Endometriose eingesetzt werden kann. Anders als andere Gestagene kann Nestoron in die Haut eindringen und so über in Form von Gel, Creme, Spray oder Implantat (Vaginalring) appliziert werden. Bei oraler Aufnahme wird die Substanz im Magen-Darm-Trakt zersetzt und zeigt so keine Wirkung. (de)
- Segesterone acetate (SGA), sold under the brand names Nestorone, Elcometrine, and Annovera, is a progestin medication which is used in birth control and in the treatment of endometriosis in the United States, Brazil, and other South American countries. It is available both alone and in combination with an estrogen. It is not effective by mouth and must be given by other routes, most typically as a vaginal ring or implant that is placed into fat. (en)
|
| rdfs:label
|
- Nestoron (de)
- Segesterone acetate (en)
|
| rdfs:seeAlso
| |
| owl:sameAs
| |
| prov:wasDerivedFrom
| |
| foaf:depiction
| |
| foaf:isPrimaryTopicOf
| |
| is dbo:wikiPageRedirects
of | |
| is dbo:wikiPageWikiLink
of | |
| is dbp:caption
of | |
| is rdfs:seeAlso
of | |
| is foaf:primaryTopic
of | |
