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The 2000–01 Buffalo Sabres season was the 31st season for the team in the National Hockey League (NHL). The Sabres finished with a 46–30–5–1 record in the regular season, and won the Conference Quarterfinals (4–2) over the Philadelphia Flyers, but lost the Conference Semifinals (4–3) to the Pittsburgh Penguins. It was also the final time they made the playoffs before the 2004–05 NHL lockout.