The 1964–65 season was the 62nd season of competitive football in Belgium. RSC Anderlechtois won their 11th Division I title and joined RU Saint-Gilloise as the club with the most championship wins in Belgium. They also won the Belgian Cup final against rivals Standard Liège (3-2 after extra time). RSC Anderlechtois entered the 1964–65 European Champion Clubs' Cup as Belgian title holder and for the first time the Cup holder ARA La Gantoise entered the European Cup Winners' Cup. RFC Liégeois, RU Saint-Gilloise and R Antwerp FC all played the 1964–65 Inter-Cities Fairs Cup. The Belgium national football team started their 1966 FIFA World Cup qualification campaign by defeating Israel 1-0.