The 2021–22 East Tennessee State Buccaneers men's basketball team represented East Tennessee State University in the 2021–22 NCAA Division I men's basketball season. The Buccaneers, led by first-year head coach Desmond Oliver, played their home games at the Freedom Hall Civic Center in Johnson City, Tennessee, as members of the Southern Conference. They finished the season 15–17, 7–11 in SoCon play to finish in eighth place. They lost to The Citadel in the first round of the SoCon tournament.