The 2021–22 Murray State Racers men's basketball team represented Murray State University in the 2021–22 NCAA Division I men's basketball season. The Racers, led by seventh-year head coach Matt McMahon, played their home games at the CFSB Center in Murray, Kentucky as members of the Ohio Valley Conference. They finished the season 31–3, 18–0 in OVC play to finish as regular season champions. As the No. 1 seed, they defeated Southeast Missouri State and Morehead State to win the OVC tournament. They received the conference's automatic bid to the NCAA tournament as the No. 7 seed in the East Region, where they defeated San Francisco in the first round before losing to Saint Peter's in the second round.