The 2021–22 Samford Bulldogs men's basketball team represented Samford University in the 2021–22 NCAA Division I men's basketball season. The Bulldogs, led by second-year head coach Bucky McMillan, played their home games at the Pete Hanna Center in Homewood, Alabama as a member of the Southern Conference. They finished the season 21–11, 10–8 in SoCon play to finish in a tie for third place. As the No. 3 seed in the SoCon tournament, they defeated UNC Greensboro before losing to Furman in the semifinals.