The 2021–22 USC Upstate Spartans men's basketball team represents the University of South Carolina Upstate in the 2021–22 NCAA Division I men's basketball season. The Spartans, led by fourth-year head coach Dave Dickerson, play their home games at the G. B. Hodge Center in Spartanburg, South Carolina as members of the Big South Conference. With the reintroduction of divisions for the first time since the 2013–14 season, the Spartans play in the South Division.