The 2021–22 Appalachian State Mountaineers men's basketball team represented Appalachian State University in the 2021–22 NCAA Division I men's basketball season. The Mountaineers, led by third-year head coach Dustin Kerns, played their home games at the Holmes Center in Boone, North Carolina as members in the Sun Belt Conference. They finished the season 19–15, 12–6 in Sun Belt play to finish in second place. They defeated Georgia Southern in the quarterfinals of the Sun Belt tournament before losing to Georgia State in the semifinals. The Mountaineers received an invitation to The Basketball Classic postseason tournament, formerly known as the CollegeInsider.com Tournament. There they lost in the first round to USC Upstate.