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- Das Overo-Lethal-White-Gen ist ein Gen, welches bei der Vererbung der Fellfarbe bei Pferden beteiligt ist. Es vererbt sich unvollständig dominant und verursacht durch eine Mutation des Endothelin-Rezeptor-B-Locus Leuzismus. Ein Pferd, welches dieses Gen nur einmal erhält, zeigt gewöhnlich eine Frame-Overo-Scheckung und ist gesund. Wird das Lethal-White-Gen von beiden Elterntieren vererbt (liegt also homozygot vor), führt es zum OLWS (Overo-Lethal-White-Syndrom). (de)
- Le syndrome du poulain blanc est une anomalie génétique létale chez le cheval, qui provoque la naissance de poulains portant une robe blanche à l'issue du croisement de deux chevaux de robe pie overo entre eux. (fr)
- Lethal white syndrome (LWS), also called overo lethal white syndrome (OLWS), lethal white overo (LWO), and overo lethal white foal syndrome (OLWFS), is an autosomal genetic disorder most prevalent in the American Paint Horse. Affected foals are born after the full 11-month gestation and externally appear normal, though they have all-white or nearly all-white coats and blue eyes. However, internally, these foals have a nonfunctioning colon. Within a few hours, signs of colic appear; affected foals die within a few days. Because the death is often painful, such foals are often humanely euthanized once identified. The disease is particularly devastating because foals are born seemingly healthy after being carried to full term. The disease has a similar cause to Hirschsprung's disease in humans. A mutation in the middle of the endothelin receptor type B (EDNRB) gene causes lethal white syndrome when homozygous. Carriers, which are heterozygous—that is, have one copy of the mutated allele, but themselves are healthy—can now be reliably identified with a DNA test. Both parents must be carriers of one copy of the LWS allele for an affected foal to be born. Horses that are heterozygous for the gene that causes lethal white syndrome often exhibit a spotted coat color pattern commonly known as "frame" or "frame overo". Coat color alone does not always indicate the presence of LWS or carrier status, however. The frame pattern may be minimally expressed or masked by other spotting patterns. Also, different genetic mechanisms produce healthy white foals and have no connection to LWS, another reason for genetic testing of potential breeding stock. Some confusion also occurs because the term overo is used to describe a number of other non tobiano spotting patterns besides the frame pattern. Though no treatment or cure for LWS foals is known, a white foal without LWS that appears ill may have a treatable condition. (en)
- Overo Lethal White Syndrom, eller OLWS, är en genetisk hästsjukdom som enbart drabbar skäckfärgade hästar, oftast Painthästar. Defekten gör även att fölet föds med ihopväxta tarmar och dör i akuta kolikattacker. Sjukdomen har alltid dödlig utgång hos fölen. Genen som orsakar defekten är densamma som ger skäckteckningen overo. Genen som styr sjukdomen är en mutation som upptäcktes första gången 1982 men det var under mitten av 1990-talet som man började forska mer om genen och hur den fungerade då många uppfödare av Painthästar vägrade att avla på ston eller hingstar som hade givit ett föl med OLWS. Forskningen visade att föl enbart kunde få OLWS om genen fanns hos båda föräldrarna och statistiskt sett blir vart fjärde föl OLWS-drabbat. (sv)
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- 37291 (xsd:nonNegativeInteger)
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- Healthy horse exhibiting the frame overo pattern. (en)
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| dbp:causes
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- Homozygous for "frame" allele on endothelin receptor B ; Ile to Lys substitution at codon 118. (en)
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- Nearly all-white coat at birth, blue eyes, DNA testing, observation for colic, no meconium, pain (en)
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- Heterozygotes have no known health issues related to the frame allele. Cremello, Dominant white and Sabino-white are normal white or near-white coat colors for healthy horses. Can be distinguished by genetic testing. (en)
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- Lethal white syndrome (en)
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- Avoid breeding heterozygous frame horses to each other (en)
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- If both parents are heterozygotes for frame, there is a 25% probability of an affected LWS foal. (en)
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| dbp:symptoms
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- Nonfunctioning colon, no meconium, colic, fatal within hours to days (en)
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- overo lethal white syndrome , lethal white overo , overo lethal white foal syndrome (en)
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- Das Overo-Lethal-White-Gen ist ein Gen, welches bei der Vererbung der Fellfarbe bei Pferden beteiligt ist. Es vererbt sich unvollständig dominant und verursacht durch eine Mutation des Endothelin-Rezeptor-B-Locus Leuzismus. Ein Pferd, welches dieses Gen nur einmal erhält, zeigt gewöhnlich eine Frame-Overo-Scheckung und ist gesund. Wird das Lethal-White-Gen von beiden Elterntieren vererbt (liegt also homozygot vor), führt es zum OLWS (Overo-Lethal-White-Syndrom). (de)
- Le syndrome du poulain blanc est une anomalie génétique létale chez le cheval, qui provoque la naissance de poulains portant une robe blanche à l'issue du croisement de deux chevaux de robe pie overo entre eux. (fr)
- Lethal white syndrome (LWS), also called overo lethal white syndrome (OLWS), lethal white overo (LWO), and overo lethal white foal syndrome (OLWFS), is an autosomal genetic disorder most prevalent in the American Paint Horse. Affected foals are born after the full 11-month gestation and externally appear normal, though they have all-white or nearly all-white coats and blue eyes. However, internally, these foals have a nonfunctioning colon. Within a few hours, signs of colic appear; affected foals die within a few days. Because the death is often painful, such foals are often humanely euthanized once identified. The disease is particularly devastating because foals are born seemingly healthy after being carried to full term. (en)
- Overo Lethal White Syndrom, eller OLWS, är en genetisk hästsjukdom som enbart drabbar skäckfärgade hästar, oftast Painthästar. Defekten gör även att fölet föds med ihopväxta tarmar och dör i akuta kolikattacker. Sjukdomen har alltid dödlig utgång hos fölen. Genen som orsakar defekten är densamma som ger skäckteckningen overo. (sv)
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| rdfs:label
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- Overo-Lethal-White-Gen (de)
- Syndrome du poulain blanc (fr)
- Lethal white syndrome (en)
- Overo lethal white syndrome (sv)
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- Lethal white syndrome (en)
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