About: Histone deacetylase inhibitor

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Histone deacetylase inhibitors (HDAC inhibitors, HDACi, HDIs) are chemical compounds that inhibit histone deacetylases. HDIs have a long history of use in psychiatry and neurology as mood stabilizers and anti-epileptics. More recently they are being investigated as possible treatments for cancers, parasitic and inflammatory diseases.

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  • Histone deacetylase inhibitors (HDAC inhibitors, HDACi, HDIs) are chemical compounds that inhibit histone deacetylases. HDIs have a long history of use in psychiatry and neurology as mood stabilizers and anti-epileptics. More recently they are being investigated as possible treatments for cancers, parasitic and inflammatory diseases. (en)
  • 組織蛋白去乙醯酶抑制劑(英語：HDAC inhibitor，簡寫HDI或HDAC抑制劑)是一種透過抑制身體內功能的藥物類別，亦存在於胎兒及花椒內。現時有健康食品生產商建議透過進食花椒油而達至的功效。 現時醫學界有研究透過「組織蛋白去乙醯酶抑制劑」來治療癌症及神经退行性疾病(neurodegenerative diseases)。這些抑制劑的具體機制，例如有關的化合物如何達到有關的功效，到現在還未清楚。不過，有關文獻亦有提出可能的表觀遺傳學途徑 Richon et al.發現HDAC抑制劑可以透過引導p21 (WAF1)來調節p53的功能。對於 HDAC 抑制劑如何調控基因表達 ，目前已有比較大的進展。持續的研究 HDAC 抑制劑的調節基因機制，將快速促進新藥設計及生物標記的鑑定 。 (zh)
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  • Histone deacetylase inhibitors (HDAC inhibitors, HDACi, HDIs) are chemical compounds that inhibit histone deacetylases. HDIs have a long history of use in psychiatry and neurology as mood stabilizers and anti-epileptics. More recently they are being investigated as possible treatments for cancers, parasitic and inflammatory diseases. (en)
  • 組織蛋白去乙醯酶抑制劑(英語：HDAC inhibitor，簡寫HDI或HDAC抑制劑)是一種透過抑制身體內功能的藥物類別，亦存在於胎兒及花椒內。現時有健康食品生產商建議透過進食花椒油而達至的功效。 現時醫學界有研究透過「組織蛋白去乙醯酶抑制劑」來治療癌症及神经退行性疾病(neurodegenerative diseases)。這些抑制劑的具體機制，例如有關的化合物如何達到有關的功效，到現在還未清楚。不過，有關文獻亦有提出可能的表觀遺傳學途徑 Richon et al.發現HDAC抑制劑可以透過引導p21 (WAF1)來調節p53的功能。對於 HDAC 抑制劑如何調控基因表達 ，目前已有比較大的進展。持續的研究 HDAC 抑制劑的調節基因機制，將快速促進新藥設計及生物標記的鑑定 。 (zh)
rdfs:label
  • Histone deacetylase inhibitor (en)
  • 組織蛋白去乙醯酶抑制劑 (zh)
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