About: Martinostat

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Martinostat is a histone deacetylase inhibitor (HDACi) that is potent against recombinant class I HDACs (isoforms 1-3) and class IIb HDAC (isoform 6) with low nanomolar affinities. In tissue CETSA assays, martinostat exhibits selectivity for class I HDACs (isoforms 1-3). When tagged with the radioisotope carbon-11, martinostat can be used to quantify HDAC in the brain and peripheral organs using positron emission tomography. Martinostat was given a name that adopted the style of other HDAC inhibitors, such as vorinostat, entinostat, and , that recognized the academic center in which it was developed, the Martinos Center for Biomedical Imaging.

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  • Martinostat is a histone deacetylase inhibitor (HDACi) that is potent against recombinant class I HDACs (isoforms 1-3) and class IIb HDAC (isoform 6) with low nanomolar affinities. In tissue CETSA assays, martinostat exhibits selectivity for class I HDACs (isoforms 1-3). When tagged with the radioisotope carbon-11, martinostat can be used to quantify HDAC in the brain and peripheral organs using positron emission tomography. Martinostat was given a name that adopted the style of other HDAC inhibitors, such as vorinostat, entinostat, and , that recognized the academic center in which it was developed, the Martinos Center for Biomedical Imaging. (en)
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  • 1629052-58-9
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  • 8JJC99KHGL
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  • CNCC23CC4CCCCC3 (en)
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  • Martinostat is a histone deacetylase inhibitor (HDACi) that is potent against recombinant class I HDACs (isoforms 1-3) and class IIb HDAC (isoform 6) with low nanomolar affinities. In tissue CETSA assays, martinostat exhibits selectivity for class I HDACs (isoforms 1-3). When tagged with the radioisotope carbon-11, martinostat can be used to quantify HDAC in the brain and peripheral organs using positron emission tomography. Martinostat was given a name that adopted the style of other HDAC inhibitors, such as vorinostat, entinostat, and , that recognized the academic center in which it was developed, the Martinos Center for Biomedical Imaging. (en)
rdfs:label
  • Martinostat (en)
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