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- Junctional Adhesion Molecule (JAM) („junktionales Adhäsionsmolekül“, lat. iunction = „Verbindung“) heißen Proteine, die zu einer Untergruppe der gehören. Sie bestehen aus 2 Immunglobulin-ähnlichen Domänen, einer Transmembrandomäne und einer kurzen zytoplasmatischen Domäne. Sie sind nur bei Wirbeltieren vorhanden. JAMs werden von einer Vielzahl verschiedener Zellen exprimiert. Man findet sie vornehmlich in Epithelzellen, Endothelzellen und Zellen des Immunsystems (Leukozyten), aber auch in Zellen des zentralen und peripheren Nervensystems, männlichen Keimzellen und Sertolizellen. In Epithelzellen und Endothelzellen sind die Junctional Adhesion Molecules Bestandteil der Tight Junctions. Innerhalb des Zytoplasmas sind die JAMs mit dem Aktin-Zytoskelett verbunden. (de)
- A junctional adhesion molecule (JAM) is a protein that is a member of the immunoglobulin superfamily, and is expressed in a variety of different tissues, such as leukocytes, platelets, and epithelial and endothelial cells. They have been shown to regulate signal complex assembly on both their cytoplasmic and extracellular domains through interaction with scaffolding that contains a PDZ domain and adjacent cell's receptors, respectively. JAMs adhere to adjacent cells through interactions with integrins LFA-1 and Mac-1, which are contained in leukocyte β2 and α4β1, which is contained in β1. JAMs have many influences on leukocyte-endothelial cell interactions, which are primarily moderated by the integrins discussed above. They interact in their cytoplasmic domain with scaffold proteins that contain a PDZ domain, which are common protein interaction modules that target short amino acid sequences at the C-terminus of proteins, to form tight junctions in both epithelial and endothelial cells as polarity is gained in the cell. (en)
- Les JAM (pour « junctional adhesion molécule ») sont une famille de protéines transmembranaires. (fr)
- JAM（Junctional adhesion molecule）は、細胞間結合の様式の1種であるタイトジャンクション（密着結合）を構成する一群のタンパク質である。 (ja)
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- 15563 (xsd:nonNegativeInteger)
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- Crystallographic structure of junctional adhesion molecules linked together (en)
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- Junctional Adhesion Molecule (en)
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- Les JAM (pour « junctional adhesion molécule ») sont une famille de protéines transmembranaires. (fr)
- JAM（Junctional adhesion molecule）は、細胞間結合の様式の1種であるタイトジャンクション（密着結合）を構成する一群のタンパク質である。 (ja)
- Junctional Adhesion Molecule (JAM) („junktionales Adhäsionsmolekül“, lat. iunction = „Verbindung“) heißen Proteine, die zu einer Untergruppe der gehören. Sie bestehen aus 2 Immunglobulin-ähnlichen Domänen, einer Transmembrandomäne und einer kurzen zytoplasmatischen Domäne. Sie sind nur bei Wirbeltieren vorhanden. JAMs werden von einer Vielzahl verschiedener Zellen exprimiert. Man findet sie vornehmlich in Epithelzellen, Endothelzellen und Zellen des Immunsystems (Leukozyten), aber auch in Zellen des zentralen und peripheren Nervensystems, männlichen Keimzellen und Sertolizellen. (de)
- A junctional adhesion molecule (JAM) is a protein that is a member of the immunoglobulin superfamily, and is expressed in a variety of different tissues, such as leukocytes, platelets, and epithelial and endothelial cells. They have been shown to regulate signal complex assembly on both their cytoplasmic and extracellular domains through interaction with scaffolding that contains a PDZ domain and adjacent cell's receptors, respectively. JAMs adhere to adjacent cells through interactions with integrins LFA-1 and Mac-1, which are contained in leukocyte β2 and α4β1, which is contained in β1. JAMs have many influences on leukocyte-endothelial cell interactions, which are primarily moderated by the integrins discussed above. They interact in their cytoplasmic domain with scaffold proteins that (en)
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- Junctional Adhesion Molecules (de)
- JAM (protéine) (fr)
- Junctional adhesion molecule (en)
- Junctional adhesion molecule (ja)
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