Sir Edward Littleton (ca. 1555 – 1610) was a Staffordshire landowner, politician and rebel from the extended Littleton/Lyttelton family. A supporter of Robert Devereux, 2nd Earl of Essex, he was the victim of a notorious electoral fraud in 1597 and a participant in the Essex Rebellion, although he escaped with his life. In the reign of James I he was elected a member of the parliament of England.