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- Totální syntéza cholesterolu je označení pro vedoucí k tvorbě cholesterolu. První takové syntézy popsali Robert Robinson a John Cornforth v roce 1951 a poté další objevili Robert Burns Woodward a o rok později. Robinsonova skupina zahájila výzkum roku 1932 a Woodwardova v roce 1949. Kolem roku 1949 bylo známo získávání steroidů, jako je kortizon, z přírodních zdrojů, což však bylo příliš nákladné. Byly dosaženy i další pokroky: v roce 1966 získal W. S. Johnson racemický cholesterol, nepřirozený enantiomer cholesterolu byl popsán v letech 1996, 2002 a 2008. (cs)
- Cholesterol total synthesis in chemistry describes the total synthesis of the complex biomolecule cholesterol and is considered a great scientific achievement. The research group of Robert Robinson with John Cornforth (Oxford University) published their synthesis in 1951 and that of Robert Burns Woodward with Franz Sondheimer (Harvard University) in 1952. Both groups competed for the first publication since 1950 with Robinson having started in 1932 and Woodward in 1949. According to historian Greg Mulheirn the Robinson effort was hampered by his micromanagement style of leadership and the Woodward effort was greatly facilitated by his good relationships with chemical industry. Around 1949 steroids like cortisone were produced from natural resources but expensive. Chemical companies Merck & Co. and Monsanto saw commercial opportunities for steroid synthesis and not only funded Woodward but also provided him with large quantities of certain chemical intermediates from pilot plants. Hard work also helped the Woodward effort: one of the intermediate compounds was named Christmasterone as it was synthesized on Christmas Day 1950 by Sondheimer. Other cholesterol schemes have also been developed: racemic cholesterol was synthesized in 1966 by W.S. Johnson, the enantiomer of natural cholesterol was reported in 1996 by Rychnovsky and Mickus, in 2002 by Jiang & Covey and again in 2008 by Rychnovsky and Belani. (en)
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- Totální syntéza cholesterolu je označení pro vedoucí k tvorbě cholesterolu. První takové syntézy popsali Robert Robinson a John Cornforth v roce 1951 a poté další objevili Robert Burns Woodward a o rok později. Robinsonova skupina zahájila výzkum roku 1932 a Woodwardova v roce 1949. Kolem roku 1949 bylo známo získávání steroidů, jako je kortizon, z přírodních zdrojů, což však bylo příliš nákladné. Byly dosaženy i další pokroky: v roce 1966 získal W. S. Johnson racemický cholesterol, nepřirozený enantiomer cholesterolu byl popsán v letech 1996, 2002 a 2008. (cs)
- Cholesterol total synthesis in chemistry describes the total synthesis of the complex biomolecule cholesterol and is considered a great scientific achievement. The research group of Robert Robinson with John Cornforth (Oxford University) published their synthesis in 1951 and that of Robert Burns Woodward with Franz Sondheimer (Harvard University) in 1952. Both groups competed for the first publication since 1950 with Robinson having started in 1932 and Woodward in 1949. According to historian Greg Mulheirn the Robinson effort was hampered by his micromanagement style of leadership and the Woodward effort was greatly facilitated by his good relationships with chemical industry. Around 1949 steroids like cortisone were produced from natural resources but expensive. Chemical companies Merck (en)
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- Totální syntéza cholesterolu (cs)
- Cholesterol total synthesis (en)
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