About: Calciseptine

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Calciseptine (CaS) is a natural neurotoxin isolated from the black mamba Dendroaspis p. polylepis venom. This toxin consists of 60 amino acids with four disulfide bonds. Calciseptine specifically blocks L-type calcium channels, but not other voltage-dependent Ca2+ channels such as N-type and T-type channels.

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  • Calciseptine (CaS) is a natural neurotoxin isolated from the black mamba Dendroaspis p. polylepis venom. This toxin consists of 60 amino acids with four disulfide bonds. Calciseptine specifically blocks L-type calcium channels, but not other voltage-dependent Ca2+ channels such as N-type and T-type channels. (en)
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  • A model of the 3D structure of calciseptine, based on an NMR structure of its homologue FS2 . Disulfide bridges are shown in yellow. The three residues that differ between FS2 and calciseptine are shown in red. (en)
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  • Dendroaspis polylepis polylepis (en)
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  • CaS (en)
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  • P22947 (en)
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  • Calciseptine (CaS) is a natural neurotoxin isolated from the black mamba Dendroaspis p. polylepis venom. This toxin consists of 60 amino acids with four disulfide bonds. Calciseptine specifically blocks L-type calcium channels, but not other voltage-dependent Ca2+ channels such as N-type and T-type channels. (en)
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  • Calciseptine (en)
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