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Statements

Subject Item
dbr:Penfluridol
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Penfluridol Penfluridolo Penfluridol Пенфлуридол Penfluridol
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Penfluridol (Semap) is een zeer krachtig antipsychoticum van de eerste generatie (typische antipsychotica). Chemisch gezien is het een difenylbutylpiperidine-derivaat. Deze stof werd in 1968 uitgevonden door Paul Janssen, stichter van Janssen Pharmaceutica. Bijzonder aan penfluridol is dat het een erg lange halfwaardetijd heeft en daardoor lang werkzaam is in de patiënt. Het medicijn is verkrijgbaar in tabletvorm waarbij één tablet een week lang werkzaam is en wordt dus bij voorkeur gegeven aan patiënten die zorg mijden of bijvoorbeeld geen injecties kunnen of willen krijgen. Penfluridol (Semap, Micefal, Longoperidol) is a highly potent, first generation diphenylbutylpiperidine antipsychotic. It was discovered at Janssen Pharmaceutica in 1968. Related to other diphenylbutylpiperidine antipsychotics, pimozide and fluspirilene, penfluridol has an extremely long elimination half-life and its effects last for many days after single oral dose. Its antipsychotic potency, in terms of dose needed to produce comparable effects, is similar to both haloperidol and pimozide. It is only slightly sedative, but often causes extrapyramidal side-effects, such as akathisia, dyskinesiae and pseudo-Parkinsonism. Penfluridol is indicated for antipsychotic treatment of chronic schizophrenia and similar psychotic disorders, it is, however, like most typical antipsychotics, being incr Пенфлуридол (Penfluridolum). 1-[4,4-Бис-(пара-фторфенил)-бутил]-4- [4-хлор-3-(трифторметил)-фенил]-4-пиперидинол Синонимы: Семап, Fluridol, Longoran, Longoperidol, Micefal, Oraleptin, Semap. Снят с продаж в России с 1999 года. В России синонимы (с тем же действующим веществом) не зарегистрированы. Il penfluridolo (conosciuto durante la fase sperimentale anche con la sigla R 16341) è una molecola dotata di proprietà antipsicotiche, un derivato di prima generazione della difenilbutilpiperidina. Rispetto ad altri derivati della difenilbutilpiperidina (ad esempio pimozide e fluspirilene), il composto presenta una emivita di eliminazione estremamente lunga, pertanto i suoi effetti perdurano per molti giorni dopo una singola assunzione orale. Le penfluridol est un neuroleptique de première génération commercialisé sous le nom de Semap. Il est utilisé dans le traitement des états psychotiques chroniques, surtout dans la schizophrénie. Le penfluridol a une durée d'action de sept jours en moyenne (entre 5 et 10 jours), il est donc administré de manière hebdomadaire.
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dbo:abstract
Le penfluridol est un neuroleptique de première génération commercialisé sous le nom de Semap. Il est utilisé dans le traitement des états psychotiques chroniques, surtout dans la schizophrénie. Le penfluridol a une durée d'action de sept jours en moyenne (entre 5 et 10 jours), il est donc administré de manière hebdomadaire. Penfluridol (Semap, Micefal, Longoperidol) is a highly potent, first generation diphenylbutylpiperidine antipsychotic. It was discovered at Janssen Pharmaceutica in 1968. Related to other diphenylbutylpiperidine antipsychotics, pimozide and fluspirilene, penfluridol has an extremely long elimination half-life and its effects last for many days after single oral dose. Its antipsychotic potency, in terms of dose needed to produce comparable effects, is similar to both haloperidol and pimozide. It is only slightly sedative, but often causes extrapyramidal side-effects, such as akathisia, dyskinesiae and pseudo-Parkinsonism. Penfluridol is indicated for antipsychotic treatment of chronic schizophrenia and similar psychotic disorders, it is, however, like most typical antipsychotics, being increasingly replaced by the atypical antipsychotics. Due to its extremely long-lasting effects, it is often prescribed to be taken orally as tablets only once a week (q 7 days). The once-weekly dose is usually 10–60 mg. A 2006 systematic review examined the use of penfluridol for people with schizophrenia: Penfluridol (Semap) is een zeer krachtig antipsychoticum van de eerste generatie (typische antipsychotica). Chemisch gezien is het een difenylbutylpiperidine-derivaat. Deze stof werd in 1968 uitgevonden door Paul Janssen, stichter van Janssen Pharmaceutica. Bijzonder aan penfluridol is dat het een erg lange halfwaardetijd heeft en daardoor lang werkzaam is in de patiënt. Het medicijn is verkrijgbaar in tabletvorm waarbij één tablet een week lang werkzaam is en wordt dus bij voorkeur gegeven aan patiënten die zorg mijden of bijvoorbeeld geen injecties kunnen of willen krijgen. Enkele jaren geleden stopte de firma Janssen met de productie van penfluridol, maar door protest (vooral uit Nederland) werd de productie overgedragen aan het Franse Alkopharma/Laboratoires Genopharm, waardoor de continuïteit ervan verzekerd leek. Arch Mei 2012 ontstonden er in Europa opnieuw grote zorgen over het niet beschikbaar zijn van dit essentiële geneesmiddel. Sinds augustus 2012 wordt het onder de merknaam ACEMAP geproduceerd door ACE Pharmaceuticals. Dit wordt sinds september 2012 ook vergoed door de zorgverzekering. Пенфлуридол (Penfluridolum). 1-[4,4-Бис-(пара-фторфенил)-бутил]-4- [4-хлор-3-(трифторметил)-фенил]-4-пиперидинол Синонимы: Семап, Fluridol, Longoran, Longoperidol, Micefal, Oraleptin, Semap. Снят с продаж в России с 1999 года. В России синонимы (с тем же действующим веществом) не зарегистрированы. Il penfluridolo (conosciuto durante la fase sperimentale anche con la sigla R 16341) è una molecola dotata di proprietà antipsicotiche, un derivato di prima generazione della difenilbutilpiperidina. Rispetto ad altri derivati della difenilbutilpiperidina (ad esempio pimozide e fluspirilene), il composto presenta una emivita di eliminazione estremamente lunga, pertanto i suoi effetti perdurano per molti giorni dopo una singola assunzione orale.
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