U.S. Route 122 (US 122) was a United States Numbered Highway that was a spur of US 22. Located in the state of Pennsylvania, it existed from 1935 to 1963. At its greatest extent, the route ran from US 1 and Pennsylvania Route 472 (PA 472) in Oxford north to US 11 and PA 14 in Northumberland. Along the way, US 122 passed through Parkesburg, Honey Brook, Morgantown, Reading, Hamburg, Schuylkill Haven, Pottsville, Frackville, Ashland, Centralia, Mount Carmel, Shamokin, and Sunbury.