U.S. Route 422 (US 422) is a 271-mile (436 km) long spur route of US 22 split into two segments in the U.S. states of Ohio and Pennsylvania. The western segment of US 422 runs from downtown Cleveland, Ohio, east to Ebensburg, Pennsylvania. The eastern segment, located entirely within Pennsylvania, runs from Hershey east to King of Prussia, near Philadelphia. US 422 Business (US 422 Bus.) serves as a business route into each of four towns along the way. Originally, US 422 was routed along existing roads, but much of the route now runs along purpose-built alignments.