The 2021–22 Presbyterian Blue Hose men's basketball team represented Presbyterian College during the 2021–22 NCAA Division I men's basketball season. The team was led by third-year head coach Quinton Ferrell, and played their home games at Templeton Physical Education Center in Clinton, South Carolina as members of the Big South Conference. The Hose finished the season 12–20, 4–12 in Big South play to finish in fifth place in the South division. As the No. 11 seed in the Big South tournament, they lost to Campbell in the first round.