The 2021–22 Eastern Illinois Panthers men's basketball team represented Eastern Illinois University in the 2021–22 NCAA Division I men's basketball season. The Panthers, led by first-year head coach Marty Simmons, played their home games at Lantz Arena in Charleston, Illinois as members of the Ohio Valley Conference. They finished the season 5–26, 3–15 in OVC play to finish in last place. They failed to qualify for the OVC Tournament.