The 2021–22 USC Trojans women's basketball team represents the University of Southern California during the 2021–22 NCAA Division I women's basketball season. The Trojans play their home games at the Galen Center and are members of the Pac-12 Conference. The squad is led by first-year head coach Lindsay Gottlieb, who was hired on May 10, 2021. Prior to arriving at USC, Gottlieb served as an assistant coach for the Cleveland Cavaliers. Her previous head coaching experience includes stops at California, whom she led to the Final Four in 2013, and UC Santa Barbara.