The 2021–22 Colorado Buffaloes women's basketball team represented the University of Colorado Boulder during the 2021–22 NCAA Division I women's basketball season. The Buffaloes, led by sixth year head coach JR Payne, played their home games at the CU Events Center and competed as members of the Pac-12 Conference. The Buffaloes were the last undefeated DI women's college basketball in the 2021-22 season, losing their first game to #2 Stanford on January 14, 2022.