The 68th Medical Group was constituted on 18 October 1927 in the Regular Army as the 18th Medical Regiment. Redesignated as the 68th Medical Regiment and reorganized as the 68th Medical Group, the organization served in combat in Europe in World War II and in the Republic of Vietnam. During the Cold War, it was stationed at Fort George G. Meade, Maryland from 1954 until its deployment to Vietnam and was reactivated again in Germany, where it served from 1978 into the 1990s.