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- Timothy John Richmond (* 9. Oktober 1948 in Corvallis) ist ein US-amerikanischer Molekularbiologe. Richmond studierte an der Purdue University mit dem Bachelor-Abschluss 1970 und wurde 1975 an der Yale University bei und Thomas A. Steitz mit einer Dissertation über Protein-DNA-Wechselwirkung promoviert. Als Post-Doktorand war er 1978 am MRC Laboratory of Molecular Biology in Cambridge bei Aaron Klug und studierte dort Chromatin. 1980 wurde er fest am Labor angestellt und klärte 1984 mit Röntgenstrukturanalyse den Aufbau des Nukleosom-Kernbestandteils bei 7 Angstrom Auflösung. Dafür erhielt er den Max Perutz Major Award. 1987 wurde er Professor an der ETH Zürich und verbesserte dort die Untersuchung des Nukleosoms in immer höherer Auflösung bis zu 2,8 Angstrom 1997 und 1,9 Angstrom 2002 (dafür erhielt er 1997 den Johnson Award der University of Pennsylvania und den Louis-Jeantet-Preis 2002). Sein Labor untersucht auch mit Röntgenstrukturanalyse verschiedene genregulierender Proteine an der DNA zum Beispiel für Transkriptionsfaktoren und die Chromatin-Fiber. 2004 wurde er Mitglied der Leopoldina, 2007 der National Academy of Sciences, 2000 der Academia Europaea, 1994 der American Association for the Advancement of Science und er wurde 1995 Mitglied der European Molecular Biology Organization (EMBO). 2006 erhielt er den Marcel-Benoist-Preis und 2002 den Louis-Jeantet-Preis. 2001 wurde er Ehrendoktor der Purdue University. (de)
- Timothy John Richmond (born October 9, 1948, in Corvallis) is an American molecular biologist, biochemist, and biophysicist. He graduated in 1970 with a bachelor's degree in biochemistry from Purdue University, where his teachers included Larry G. Butler (died 1997) and Michael G. Rossmann. Richmond graduated in 1975 from Yale University's department of molecular biophysics and biochemistry with a dissertation on protein-DNA interaction under the supervision of Frederic M. Richards and Thomas A. Steitz. Richmond was a postdoc at Yale University from 1975 to 1978 under the supervision of Frederic M. Richards and from 1978 to 1980 at the MRC Laboratory of Molecular Biology under the supervision of Sir Aaron Klug studying the nucleosome (which is the fundamental subunit of chromatin). Richmond was from 1980 to 1987 a tenured staff scientist at the MRC Laboratory of Molecular Biology and in 1987 was appointed "Professor of X-ray Crystallography of Biological Macromolecules" at ETH Zurich's Institute for Molecular Biology and Biophysics. At ETH Zurich he became in 2005 vice-chair of the biology department. Richmond’s work provides a basis for integrating decades of biochemical, physical, and genetic studies of chromatin. His focus has been to establish the atomic structures of large macromolecular assemblies, particularly those involved in protein-DNA complexes and to relate these structures to the biological processes of chromatin assembly and transcription regulation. The interests of Prof. Richmond in teaching and research are primarily devoted to the recognition and assembly of biological macromolecular complexes. X-ray crystallography, cryo-electron microscopy and other biophysical and biochemical techniques are employed by his laboratory. The focus of his research is on the organization of DNA in chromosomes and the regulation of gene expression in higher organisms. His laboratory has elucidated the structures of the nucleosome core particle and various transcription factor complexes. Their work on the nucleosome core particle, the fundamental repeating unit of chromatin, resulted ultimately in its atomic description at 1.9 å resolution. They have since determined the organization of nucleosomes in the chromatin fiber. He was the postdoctoral supervisor of Karolin Luger. Richmond was elected in 1994 a fellow of the American Association for the Advancement of Science (AAAS). He was elected a member in 1995 of the European Molecular Biology Organization (EMBO), in 2000 of the Academia Europaea, in 2004 of the German National Academy of Sciences Leopoldina, and in 2007 of the U.S. National Academy of Sciences. In 2001 he was awarded an honorary doctor of science degree by Purdue University. His prizes or awards include the Louis-Jeantet Prize for Medicine in 2002 and the Marcel Benoist Prize in 2006. (en)
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- Timothy John Richmond (* 9. Oktober 1948 in Corvallis) ist ein US-amerikanischer Molekularbiologe. Richmond studierte an der Purdue University mit dem Bachelor-Abschluss 1970 und wurde 1975 an der Yale University bei und Thomas A. Steitz mit einer Dissertation über Protein-DNA-Wechselwirkung promoviert. Als Post-Doktorand war er 1978 am MRC Laboratory of Molecular Biology in Cambridge bei Aaron Klug und studierte dort Chromatin. 1980 wurde er fest am Labor angestellt und klärte 1984 mit Röntgenstrukturanalyse den Aufbau des Nukleosom-Kernbestandteils bei 7 Angstrom Auflösung. Dafür erhielt er den Max Perutz Major Award. 1987 wurde er Professor an der ETH Zürich und verbesserte dort die Untersuchung des Nukleosoms in immer höherer Auflösung bis zu 2,8 Angstrom 1997 und 1,9 Angstrom 2002 (d (de)
- Timothy John Richmond (born October 9, 1948, in Corvallis) is an American molecular biologist, biochemist, and biophysicist. He graduated in 1970 with a bachelor's degree in biochemistry from Purdue University, where his teachers included Larry G. Butler (died 1997) and Michael G. Rossmann. Richmond graduated in 1975 from Yale University's department of molecular biophysics and biochemistry with a dissertation on protein-DNA interaction under the supervision of Frederic M. Richards and Thomas A. Steitz. Richmond was a postdoc at Yale University from 1975 to 1978 under the supervision of Frederic M. Richards and from 1978 to 1980 at the MRC Laboratory of Molecular Biology under the supervision of Sir Aaron Klug studying the nucleosome (which is the fundamental subunit of chromatin). Richmon (en)
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- Timothy J. Richmond (de)
- Timothy J. Richmond (en)
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