| dbo:abstract
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- Protein acetylation (and deacetylation) are acetylation reactions that occur within living cells as drug metabolism, by enzymes in the liver and other organs (e. g., the brain). Pharmaceuticals frequently employ acetylation to enable such esters to cross the blood–brain barrier (and placenta), where they are deacetylated by enzymes (carboxylesterases) in a manner similar to acetylcholine. Examples of acetylated pharmaceuticals are diacetylmorphine (heroin), acetylsalicylic acid (aspirin), THC-O-acetate, and diacerein. Conversely, drugs such as isoniazid are acetylated within the liver during drug metabolism. A drug that depends on such metabolic transformations in order to act is termed a prodrug. Acetylation is an important modification of proteins in cell biology; and proteomics studies have identified thousands of acetylated mammalian proteins. Acetylation occurs as a co-translational and post-translational modification of proteins, for example, histones, p53, and tubulins. Among these proteins, chromatin proteins and metabolic enzymes are highly represented, indicating that acetylation has a considerable impact on gene expression and metabolism. In bacteria, 90% of proteins involved in central metabolism of Salmonella enterica are acetylated. (en)
- 단백질 아세틸화(영어: protein acetylation)는 간 및 기타 기관(예: 뇌)의 효소에 의해 약물 대사로서 살아있는 세포 내에서 일어나는 아세틸화 반응으로 번역 후 변형의 한 유형이다. 제약은 보통 아세틸화를 사용하여 이러한 에스터가 혈뇌장벽(및 태반)을 통과할 수 있도록 하며, 아세틸콜린과 유사한 방식으로 효소(카복실에스터레이스)에 의해 탈아세틸화된다. (ko)
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| rdfs:comment
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- 단백질 아세틸화(영어: protein acetylation)는 간 및 기타 기관(예: 뇌)의 효소에 의해 약물 대사로서 살아있는 세포 내에서 일어나는 아세틸화 반응으로 번역 후 변형의 한 유형이다. 제약은 보통 아세틸화를 사용하여 이러한 에스터가 혈뇌장벽(및 태반)을 통과할 수 있도록 하며, 아세틸콜린과 유사한 방식으로 효소(카복실에스터레이스)에 의해 탈아세틸화된다. (ko)
- Protein acetylation (and deacetylation) are acetylation reactions that occur within living cells as drug metabolism, by enzymes in the liver and other organs (e. g., the brain). Pharmaceuticals frequently employ acetylation to enable such esters to cross the blood–brain barrier (and placenta), where they are deacetylated by enzymes (carboxylesterases) in a manner similar to acetylcholine. Examples of acetylated pharmaceuticals are diacetylmorphine (heroin), acetylsalicylic acid (aspirin), THC-O-acetate, and diacerein. Conversely, drugs such as isoniazid are acetylated within the liver during drug metabolism. A drug that depends on such metabolic transformations in order to act is termed a prodrug. (en)
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