Karen Rae Tallian (born December 2, 1950) is an American politician and attorney who served as a member of the Indiana Senate for the 4th district from December 2005 through October 2021. She was re-elected in 2006, 2010 and 2014. While serving in the Senate, Tallian, a progressive, has supported medicinal prescription and the decriminalization of marijuana, and has authored bills in its favor. In 2015, she announced her candidacy for governor of Indiana but dropped out that same year, well before the primary season. Tallian was also a candidate for the Democratic Party nomination for Indiana Attorney General in 2020, but lost the nomination to Jonathan Weinzapfel.