James Vann (c. 1762–64 – February 19, 1809) was an influential Cherokee leader, one of the triumvirate with Major Ridge and Charles R. Hicks, who led the Upper Towns of East Tennessee and North Georgia as part of the ᎤᏪᏘ ᏣᎳᎩ ᎠᏰᎵ (Uwet Tsalag Ayetl or Old Cherokee Nation). He was the son of ᏩᎵ (Wali) Vann and Indian trader Joseph John Vann. He was born into his mother's Clan, ᎠᏂᎪᏓᎨᏫ (Anigodagewi or Wild Potato Clan, also called Blind Savannah Clan).