James DeSano is a retired orchestral trombonist. He served as associate principal trombone of the Cleveland Orchestra from 1970 to 1989 and as principal trombone from 1989 to his retirement in 2003. As a soloist with the Cleveland Orchestra, he performed Henri Tomasi's Trombone Concerto. Prior to his tenure in Cleveland, DeSano was principal trombone of the Syracuse Symphony Orchestra from 1964 to 1970.