Sir George Wakeman (died 1688) was an English doctor, who was royal physician to Catherine of Braganza, Consort of Charles II of England. In 1678, in the allegations of the fabricated Popish Plot, he was falsely accused of treason by Titus Oates, who had gained the backing of Thomas Osborne, 1st Earl of Danby, the effective head of the English government. Oates accused Wakeman of conspiring to kill the King with the help of the Jesuits, and to put his brother James, Duke of York on the throne in his place. At his trial in 1679 Wakeman was acquitted, the first sign that the public was beginning to lose faith in the reality of the Plot.