There were six early Barons Inchiquin in Ireland between 1543 and 1654. The title was granted to Murrough O'Brien, the brother of Conor O'Brien, King of Thomond, when he surrendered his Irish royalty to King Henry VIII in 1543. His descendants held the title until 1654, when Murrough O'Brien, 6th Baron Inchiquin was created Earl of Inchiquin.