About: CBS domain

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In molecular biology, the CBS domain is a protein domain found in a range of proteins in all species from bacteria to humans. It was first identified as a conserved sequence region in 1997 and named after cystathionine beta synthase, one of the proteins it is found in. CBS domains are also found in a wide variety of other proteins such as inosine monophosphate dehydrogenase, voltage gated chloride channels and AMP-activated protein kinase (AMPK). CBS domains regulate the activity of associated enzymatic and transporter domains in response to binding molecules with adenosyl groups such as AMP and ATP, or s-adenosylmethionine.

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  • In molecular biology, the CBS domain is a protein domain found in a range of proteins in all species from bacteria to humans. It was first identified as a conserved sequence region in 1997 and named after cystathionine beta synthase, one of the proteins it is found in. CBS domains are also found in a wide variety of other proteins such as inosine monophosphate dehydrogenase, voltage gated chloride channels and AMP-activated protein kinase (AMPK). CBS domains regulate the activity of associated enzymatic and transporter domains in response to binding molecules with adenosyl groups such as AMP and ATP, or s-adenosylmethionine. (en)
  • CBSドメイン（英: CBS domain）は、細菌からヒトまですべての生物種でさまざまなタンパク質に存在するタンパク質ドメインである。CBSドメインは1997年に保存配列領域として初めて同定され、その名称はこのドメインを持つタンパク質の1つである、に由来する。CBSドメインは他にもイノシン一リン酸デヒドロゲナーゼ（IMPDH）、やAMP活性化プロテインキナーゼ（AMPK）など、幅広いタンパク質に存在する。CBSドメインは、AMPやATP、S-アデノシルメチオニンなど、アデノシル基を持つ分子の結合に応答して酵素や輸送体の活性を調節する。 (ja)
dbo:symbol
  • CBS
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  • 26693928 (xsd:integer)
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  • 17927 (xsd:nonNegativeInteger)
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  • 1115468455 (xsd:integer)
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dbp:caption
  • Structure of the yeast SNF4 protein that contains four CBS domains. This protein is part of the AMP-activated protein kinase complex. (en)
dbp:cdd
  • cd02205 (en)
dbp:interpro
  • IPR000644 (en)
dbp:name
  • CBS domain (en)
dbp:pdb
  • , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , (en)
dbp:pfam
  • PF00571 (en)
dbp:prosite
  • PS51371 (en)
dbp:scop
  • 1 (xsd:integer)
dbp:smart
  • CBS (en)
dbp:symbol
  • CBS (en)
dbp:width
  • 350 (xsd:integer)
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rdfs:comment
  • In molecular biology, the CBS domain is a protein domain found in a range of proteins in all species from bacteria to humans. It was first identified as a conserved sequence region in 1997 and named after cystathionine beta synthase, one of the proteins it is found in. CBS domains are also found in a wide variety of other proteins such as inosine monophosphate dehydrogenase, voltage gated chloride channels and AMP-activated protein kinase (AMPK). CBS domains regulate the activity of associated enzymatic and transporter domains in response to binding molecules with adenosyl groups such as AMP and ATP, or s-adenosylmethionine. (en)
  • CBSドメイン（英: CBS domain）は、細菌からヒトまですべての生物種でさまざまなタンパク質に存在するタンパク質ドメインである。CBSドメインは1997年に保存配列領域として初めて同定され、その名称はこのドメインを持つタンパク質の1つである、に由来する。CBSドメインは他にもイノシン一リン酸デヒドロゲナーゼ（IMPDH）、やAMP活性化プロテインキナーゼ（AMPK）など、幅広いタンパク質に存在する。CBSドメインは、AMPやATP、S-アデノシルメチオニンなど、アデノシル基を持つ分子の結合に応答して酵素や輸送体の活性を調節する。 (ja)
rdfs:label
  • CBS domain (en)
  • CBSドメイン (ja)
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