The 2021–22 Liga I was the 32nd season of the top level women's football league of the Romanian football league system. 12 teams played a one legged-round robin. The top 6 teams progressed then to the play-offs, while the bottom 6 teams to the play-out, where a two-legged round-robin took place. Teams ranked 11 and 12 (5 and 6 in the play-out) would relegate directly to the 2022–23 Liga II. U Olimpia Cluj were the defending champions.