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Statements

Subject Item
dbr:Cation_channel_superfamily
rdf:type
wikidata:Q206229 dbo:Protein owl:Thing dbo:Biomolecule wikidata:Q8054
rdfs:label
Cation channel superfamily
rdfs:comment
The transmembrane cation channel superfamily was defined in InterPro and Pfam as the family of tetrameric ion channels. These include the sodium, potassium, calcium, ryanodine receptor, HCN, CNG, CatSper, and TRP channels. This large group of ion channels apparently includes families 1.A.1, 1.A.2, 1.A.3, and 1.A.4 of the TCDB transporter classification.
rdfs:seeAlso
dbr:Voltage-gated_ion_channel
dbp:name
Ion channel
foaf:depiction
n12:2r9r_opm.png n12:1r3j.png
dct:subject
dbc:Transmembrane_proteins dbc:Protein_families dbc:Protein_domains dbc:Ion_channels
dbo:wikiPageID
14709342
dbo:wikiPageRevisionID
1069888122
dbo:wikiPageWikiLink
dbr:TRPM2 dbr:KCNK7 dbr:CACNA1F dbr:KCNK9 dbr:CACNA1S dbr:KCNQ2 dbr:KCNQ3 dbr:KCNK10 dbr:KCNK12 dbr:KCNK13 dbr:KCNK15 dbr:KCNK16 dbr:KCNK17 dbr:KCNK18 dbr:KCNK2 dbr:KCNQ1 dbr:TRPA1 dbr:KCNH2 dbr:TRPM1 dbr:KCNK1 dbr:KCNH8 dbr:TRPV1 dbr:KCND2 dbr:Vestigiality dbr:Transient_receptor_potential_channels dbr:KCNG2 dbr:KCNA1 dbr:KCNG3 dbr:TRPM6 dbr:KCNG4 dbr:Ryanodine_receptor dbr:KCNH1 dbr:MCOLN3 dbr:KCNH3 dbr:KCNH4 dbr:KCNH6 dbr:KCNH7 dbr:RYR1 dbr:Transmembrane_domain dbr:KCND1 dbr:RYR3 dbr:KCNF1 dbr:KCNG1 dbr:Heterotetramer dbr:KCNB1 dbr:MCOLN1 dbr:KCNB2 dbr:KCNC1 dbr:TRPC6 dbr:KCNC2 dbr:TRPM4 dbr:KCNC3 dbr:KCNC4 dbr:Potassium_ion_channels dbr:KCNA10 dbr:KCNA2 dbr:KCNA3 dbr:KCNA4 dbr:KCNA5 dbr:KCNA6 dbr:KCNA7 dbr:KvLQT1 dbr:CACNA1B dbr:CACNA1G dbr:CACNA1I dbr:SLC9A11 dbr:KCNV1 dbr:KCNV2 dbr:SCN8A dbr:KCNQ5 dbc:Transmembrane_proteins dbr:KCNS1 dbr:KCNS2 dbr:KCNS3 dbr:TRPC1 dbr:KCNT1 dbr:KCNT2 dbr:TRPV2 dbr:KCNN1 dbr:KCNN2 dbr:KCNN4 dbr:SCN1A dbr:TPTE dbr:SCN2A dbr:KCNQ4 dbr:SCN3A dbr:SCN5A dbr:HCN2 dbr:HCN3 dbr:HCN4 dbr:TRPM8 dbr:HCN_channel dbr:KCNH5 dbr:Voltage_sensitive_phosphatase dbc:Protein_domains dbr:Voltage-gated_ion_channel dbr:HCN1 dbr:Ion_selectivity dbr:SCN11A dbr:SCN2A2 dbr:ITPR2 dbr:TRPV4 dbr:SCN4A dbr:ITPR3 dbr:KCND3 dbc:Protein_families dbr:TPCN1 dbr:Pfam dbr:TRPM5 dbr:ITPR1 dbr:MCOLN2 dbr:Tetrameric_protein dbr:Transporter_Classification_Database dbr:Ether-a-go-go_potassium_channels dbr:TRPC4 dbr:CACNA1H dbr:TPCN2 dbr:TRPM3 dbr:KCNU1 dbr:TRPC5 dbr:TRPV5 dbr:TRPV6 dbr:Inward-rectifier_potassium_channel dbr:SCN9A dbr:KCNN3 dbr:Ion_channels dbr:CNG_channel dbr:CNGA4 dbr:CNGB3 dbr:KcsA_potassium_channel dbc:Ion_channels dbr:Cation_channels_of_sperm dbr:Lipid_bilayer dbr:SCN10A dbr:CNGA1 dbr:CNGA2 dbr:CNGA3 dbr:NALCN dbr:TRPV3 dbr:KCNMA1 dbr:InterPro dbr:R-type_calcium_channel dbr:Sodium_ion_channels dbr:Shaker_superfamily_of_potassium_channels dbr:SLC9A10 dbr:TRPM7 dbr:TRPC7 dbr:CATSPER2 dbr:CATSPER3 dbr:CATSPER4 dbr:CNGB1 dbr:HERG dbr:Voltage-dependent_calcium_channel dbr:CATSPER1 dbr:HVCN1 dbr:TRPC3 dbr:RYR2 dbr:PKD1L3 dbr:KCNK3 dbr:Homotetramer dbr:CACNA1A dbr:KCNK4 dbr:SCN7A dbr:CACNA1C dbr:KCNK5 dbr:CACNA1D dbr:KCNK6
dbo:wikiPageExternalLink
n16:ReceptorFamiliesForward%7C
owl:sameAs
n15:8BdwP wikidata:Q83138248
dbp:tcdb
1
dbp:wikiPageUsesTemplate
dbt:PDB3 dbt:Cite_web dbt:Reflist dbt:Pfam_box dbt:Main dbt:TCDB dbt:Gene dbt:Pfam dbt:See_also dbt:InterPro_content dbt:Short_description
dbo:thumbnail
n12:2r9r_opm.png?width=300
dbp:scop
1
dbp:caption
Potassium channel Kv1.2 , structure in a membrane-like environment. Calculated hydrocarbon boundaries of the lipid bilayer are indicated by red and blue dots. Potassium channel KcsA. Calculated hydrocarbon boundaries of the lipid bilayer are indicated by red and blue dots.
dbp:interpro
IPR005821 IPR013099
dbp:pfam
PF07885 PF00520
dbp:symbol
Ion_trans_2 Ion_trans
dbp:width
250
dbo:abstract
The transmembrane cation channel superfamily was defined in InterPro and Pfam as the family of tetrameric ion channels. These include the sodium, potassium, calcium, ryanodine receptor, HCN, CNG, CatSper, and TRP channels. This large group of ion channels apparently includes families 1.A.1, 1.A.2, 1.A.3, and 1.A.4 of the TCDB transporter classification. They are described as minimally having two transmembrane helices flanking a loop which determines the of the channel pore. Many eukaryotic channels have four additional transmembrane helices (TM) (Pfam PF00520), related to or vestigial of voltage gating. The proteins with only two transmembrane helices (Pfam PF07885) are most commonly found in bacteria. This also includes the 2-TM inward-rectifier potassium channels (Pfam PF01007) found primarily in eukaryotes. There are commonly additional regulatory domains which serve to regulate ion conduction and channel gating. The pores may also be homotetramers or heterotetramers; where heterotetramers may be encoded as distinct genes or as multiple pore domains within a single polypeptide. The HVCN1 and Putative tyrosine-protein phosphatase proteins do not contain an expected ion conduction pore domain, but rather have homology only to the voltage sensor domain of voltage gated ion channels.
dbp:opmFamily
8
dbp:opmProtein
2 1
dbp:pdb
E:25-100 B:169-250 C:169-250 C:34-116 C:34-116 C:34-116 C:34-116 C:34-116 B:34-116 C:34-116 D:34-116 C:34-116 C:34-116 C:34-116 C:34-116 B:77-151 A:157-176 B:225-409 A:378-397 A:378-397 A:570-611
prov:wasDerivedFrom
wikipedia-en:Cation_channel_superfamily?oldid=1069888122&ns=0
dbo:wikiPageLength
18911
dbo:symbol
Ion_trans Ion_trans_2
foaf:isPrimaryTopicOf
wikipedia-en:Cation_channel_superfamily