About: Synthetic ion channels

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Synthetic ion channels are de novo chemical compounds that insert into lipid bilayers, form pores, and allow ions to flow from one side to the other. They are man-made analogues of natural ion channels, and are thus also known as artificial ion channels. Compared to biological channels, they usually allow fluxes of similar magnitude but are 1. * minuscule in size (less than 5k Dalton vs. > 100k Dalton), 2. * diverse in molecular architecture, and 3. * may rely on diverse supramolecular interactions to pre-form the active, conducting structures.

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  • Synthetic ion channels are de novo chemical compounds that insert into lipid bilayers, form pores, and allow ions to flow from one side to the other. They are man-made analogues of natural ion channels, and are thus also known as artificial ion channels. Compared to biological channels, they usually allow fluxes of similar magnitude but are 1. * minuscule in size (less than 5k Dalton vs. > 100k Dalton), 2. * diverse in molecular architecture, and 3. * may rely on diverse supramolecular interactions to pre-form the active, conducting structures. Synthetic channels, like natural channels, are usually characterized by a combination of single-molecule (e.g., voltage-clamp of planar bilayers) and ensemble techniques (flux in vesicles). The study of synthetic ion channels can potentially lead to new single-molecule sensing technologies as well as new therapeutics. (en)
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  • Synthetic ion channels are de novo chemical compounds that insert into lipid bilayers, form pores, and allow ions to flow from one side to the other. They are man-made analogues of natural ion channels, and are thus also known as artificial ion channels. Compared to biological channels, they usually allow fluxes of similar magnitude but are 1. * minuscule in size (less than 5k Dalton vs. > 100k Dalton), 2. * diverse in molecular architecture, and 3. * may rely on diverse supramolecular interactions to pre-form the active, conducting structures. (en)
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  • Synthetic ion channels (en)
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