About: Alamethicin

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Alamethicin is a channel-forming peptide antibiotic, produced by the fungus Trichoderma viride. It belongs to peptaibol peptides which contain the non-proteinogenic amino acid residue Aib (2-aminoisobutyric acid). This residue strongly induces formation of alpha-helical structure. The peptide sequence is: Ac-Aib-Pro-Aib-Ala-Aib-Ala-Gln-Aib-Val-Aib-Gly-Leu-Aib-Pro-Val-Aib-Aib-Glu-Gln-Phl (Ac = acetyl, Phl = , Aib = 2-Aminoisobutyric acid) In cell membranes, it forms voltage-dependent ion channels by aggregation of four to six molecules.

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  • Alamethicin is a channel-forming peptide antibiotic, produced by the fungus Trichoderma viride. It belongs to peptaibol peptides which contain the non-proteinogenic amino acid residue Aib (2-aminoisobutyric acid). This residue strongly induces formation of alpha-helical structure. The peptide sequence is: Ac-Aib-Pro-Aib-Ala-Aib-Ala-Gln-Aib-Val-Aib-Gly-Leu-Aib-Pro-Val-Aib-Aib-Glu-Gln-Phl (Ac = acetyl, Phl = , Aib = 2-Aminoisobutyric acid) In cell membranes, it forms voltage-dependent ion channels by aggregation of four to six molecules. (en)
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  • N-acetyl-2-methylalanyl-(L)-prolyl-2-methylalanyl-(L)-alanyl-2-methylalanyl-(L)-alanyl-(L)-glutaminyl-2-methylalanyl-(L)-valyl-2-methylalanylglycyl-(L)-leucyl-2-methylalanyl-(L)-prolyl-(L)-valyl-2-methylalanyl-2-methylalanyl-(L)-α-glutamyl-N1-[(1S)-1-benzyl-2-hydroxyethyl]-(L)-glutamamide (en)
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  • N-acetyl-2-methylalanyl-(L)-prolyl-2-methylalanyl-(L)-alanyl-2-methylalanyl-(L)-alanyl-(L)-glutaminyl-2-methylalanyl-(L)-valyl-2-methylalanylglycyl-(L)-leucyl-2-methylalanyl-(L)-prolyl-(L)-valyl-2-methylalanyl-2-methylalanyl-(L)-α-glutamyl-N1-[-1-benzyl-2-hydroxyethyl]-(L)-glutamamide (en)
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  • Alamethicin is a channel-forming peptide antibiotic, produced by the fungus Trichoderma viride. It belongs to peptaibol peptides which contain the non-proteinogenic amino acid residue Aib (2-aminoisobutyric acid). This residue strongly induces formation of alpha-helical structure. The peptide sequence is: Ac-Aib-Pro-Aib-Ala-Aib-Ala-Gln-Aib-Val-Aib-Gly-Leu-Aib-Pro-Val-Aib-Aib-Glu-Gln-Phl (Ac = acetyl, Phl = , Aib = 2-Aminoisobutyric acid) In cell membranes, it forms voltage-dependent ion channels by aggregation of four to six molecules. (en)
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  • Alamethicin (en)
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