Jacob Cruucke or Jacob van Cruyck, also known by his Latinized name Jacobus Cruquius and in French-language literature as Jacques de Crucque (Mesen, before 1520 - 22 June 1584) was a Flemish humanist, philologist, and scholar of the 16th century. He is mainly known for his publications on the works of the Roman lyric poet Horace based on ancient manuscripts kept in the library of a local monastery, since lost to fire.