The Magdeburg-Wittenberge railway is a two-track, electrified main line in the east of the German state of Saxony-Anhalt. It is one of the oldest lines in Germany, opened in 1849 by the Magdeburg-Wittenberge Railway Company, which operated it until 1863, when it was taken over by the Magdeburg-Halberstadt Railway Company. It was nationalised in 1879.