About: CRAM (file format)

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Compressed Reference-oriented Alignment Map (CRAM) is a compressed columnar file format for storing biological sequences aligned to a reference sequence, initially devised by Markus Hsi-Yang Fritz et al. Implementations of CRAM exist in htsjdk, htslib, JBrowse, and Scramble. The file format specification is maintained by the Global Alliance for Genomics and Health (GA4GH) with the specification document available from the EBI cram toolkit page.

Attributes	Values
rdfs:label	CRAM (file format) (en)
rdfs:comment	Compressed Reference-oriented Alignment Map (CRAM) is a compressed columnar file format for storing biological sequences aligned to a reference sequence, initially devised by Markus Hsi-Yang Fritz et al. Implementations of CRAM exist in htsjdk, htslib, JBrowse, and Scramble. The file format specification is maintained by the Global Alliance for Genomics and Health (GA4GH) with the specification document available from the EBI cram toolkit page. (en)
name	CRAM (en)
dcterms:subject	Bioinformatics Science and technology in Cambridgeshire South Cambridgeshire District Biological sequence format
Wikipage page ID	58749955 (xsd:integer)
Wikipage revision ID	1123603419 (xsd:integer)
Link from a Wikipage to another Wikipage	Python (programming language) List of file formats Sequence alignment Bioinformatics SAMtools Lempel–Ziv–Markov chain algorithm C (programming language) Wellcome Sanger Institute Science and technology in Cambridgeshire European Bioinformatics Institute Global Alliance for Genomics and Health (GA4GH) Asymmetric numeral systems Java (programming language) South Cambridgeshire District Binary Alignment Map Bioinformatics RefSeq Biological sequence format Huffman coding SAM (file format) Compression of Genomic Re-Sequencing Data JBrowse
Link from a Wikipage to an external page	https://www.ga4gh.org/cram/ https://www.ebi.ac.uk/ena/software/cram-toolkit
sameAs	CRAM (file format) CRAM (file format)
dbp:wikiPageUsesTemplate	dbt:Infobox_file_format dbt:Reflist dbt:Bioinformatics
developer	Markus Hsi-Yang Fritz et al; Vadim Zalunin ; James Bonfield (en)
extension	.cram (en)
genre	Bioinformatics
open	yes (en)
url	https://www.ga4gh.org/cram/ https://www.ebi.ac.uk/ena/software/cram-toolkit
has abstract	Compressed Reference-oriented Alignment Map (CRAM) is a compressed columnar file format for storing biological sequences aligned to a reference sequence, initially devised by Markus Hsi-Yang Fritz et al. CRAM was designed to be an efficient reference-based alternative to the Sequence Alignment Map (SAM) and Binary Alignment Map (BAM) file formats. It optionally uses a genomic reference to describe differences between the aligned sequence fragments and the reference sequence, reducing storage costs. Additionally each column in the SAM format is separated into its own blocks, improving compression ratio. CRAM files typically vary from 30 to 60% smaller than BAM, depending on the data held within them. Implementations of CRAM exist in htsjdk, htslib, JBrowse, and Scramble. The file format specification is maintained by the Global Alliance for Genomics and Health (GA4GH) with the specification document available from the EBI cram toolkit page. (en)
prov:wasDerivedFrom	wikipedia-en:CRAM_(file_format)?oldid=1123603419&ns=0
page length (characters) of wiki page	7523 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:CRAM_(file_format)
is Link from a Wikipage to another Wikipage of	List of file formats List of filename extensions (A–E) .crai SAMtools Timeline of information theory MPEG-G Compression of genomic sequencing data Cram Asymmetric numeral systems Binary Alignment Map
is Wikipage redirect of	.crai
is Wikipage disambiguates of	Cram
is foaf:primaryTopic of	wikipedia-en:CRAM_(file_format)

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