The 2021–22 Syed Mushtaq Ali Trophy was the fourteenth season of the Syed Mushtaq Ali Trophy, a Twenty20 cricket tournament played in India. It was contested by 38 teams, divided into six groups, with six teams in Group D. The tournament was announced by BCCI on 3 July 2021. Gujarat won four of their five matches, with Kerala winning three matches. Therefore, Gujarat advanced to the quarter-finals and Kerala progressed to the preliminary quarter-finals by winning their last league match against Madhya Pradesh.