2021–22 Syed Mushtaq Ali Trophy (also known as Paytm Syed Mushtaq Ali Trophy due to sponsorship reasons) was the fourteenth edition of Syed Mushtaq Ali Trophy, a Twenty20 competition that was played in India. It started on 4 November 2021, with the final taking place on 22 November 2021. The tournament formed part of the 2021–22 Indian domestic cricket season, which was announced by the Board of Control for Cricket in India (BCCI) in July 2021. Tamil Nadu were the defending champions.