The 2021–22 Southern Illinois Salukis men's basketball team represented Southern Illinois University Carbondale during the 2021–22 NCAA Division I men's basketball season. The Salukis were led by third-year head coach Bryan Mullins and played their home games at the Banterra Center in Carbondale, Illinois as members of the Missouri Valley Conference. They finished the season 16–15, 9–9 in MVC play to finish in sixth place. They lost in the quarterfinals of the MVC tournament to Drake.