The 2021–22 Loyola Ramblers men's basketball team represented Loyola University Chicago during the 2021–22 NCAA Division I men's basketball season. The Ramblers, led by first-year head coach Drew Valentine, played their home games at the Joseph J. Gentile Arena in Chicago, Illinois as members of the Missouri Valley Conference. They finished the regular season 25–7, 13–5 in MVC play to finish in a three-way tie for second place. As the No. 4 seed in the MVC tournament, they defeated Bradley, Northern Iowa, and Drake to win the MVC tournament for the second consecutive season. As a result, they received the conference's automatic bid to the NCAA tournament as the No. 10 seed, where they lost in the first round to Ohio State.