The 2021–22 Saint Louis Billikens men's basketball team represented Saint Louis University during the 2021–22 NCAA Division I men's basketball season. Their head coach is Travis Ford in his sixth season at Saint Louis. The team played their home games at Chaifetz Arena as a member of the Atlantic 10 Conference. They finished the season 23–12, 12–6 in A-10 Play to finish in fifth place. They defeated La Salle and St. Bonaventure to advance to the semifinals of the A-10 tournament where they lost to Davidson. They received an at-large bid to the National Invitation Tournament where they lost in the first round to Northern Iowa.