The 2021–22 season was the 130th season in the existence of SK Slavia Prague and the club's 29th consecutive season in the top flight of Czech football. Domestically, Slavia finished the season 2nd in the league and reached the Quarterfinal's of the Czech Cup. In Europe, Slavia where knocked out of the Champions League at the Third qualifying round stage by Ferencváros, the Play-off round of the UEFA Europa League by Legia Warsaw and reached the Quarterfinal of the UEFA Europa Conference League where they were defeated by Feyenoord.