The 2015–16 SIU Edwardsville Cougars men's basketball team represented Southern Illinois University Edwardsville during the 2015–16 NCAA Division I men's basketball season. The Cougars, led by first year head coach Jon Harris, played their home games at the Vadalabene Center as members of the West Division of the Ohio Valley Conference (OVC). They finished the season 6–22, 3–13 in OVC play to finish in fifth place in the west division. They failed to qualify for the OVC tournament.